Epithelial-mesenchymal transition and inflammation at the site of the primary tumor.
Epithelial-mesenchymal transition and inflammation at the site of the primary tumor.
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DOI：
10.1016/j.semcancer.2017.08.002
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发表时间：
2017-12
影响因子：
14.5
通讯作者：
Palena C
中科院分区：
文献类型：
--
作者：
Dominguez C;David JM;Palena C
肿瘤生长和进展是肿瘤及其周围基质中不同细胞类型之间复杂信号网络的产物。特别地，已知已建立的肿瘤通过分泌细胞因子、趋化因子和生长因子来刺激炎症反应，所述细胞因子、趋化因子和生长因子有利于将一系列浸润免疫细胞群体募集到肿瘤微环境中。虽然可能能够发挥肿瘤控制，但这种炎症反应通常被肿瘤抓住，以促进其自身的生长和向转移的进展。本文综述了近年来在了解已建立的肿瘤如何通过释放促炎介质（如IL-6和IL-8）启动炎症反应及其在癌症转移中的作用方面的进展。特别是，这里讨论了上皮-间充质转化（EMT）与癌症炎症的关系，EMT是在癌症中观察到的一种表型转变，可促进转移的进展。
Tumor growth and progression are the products of complex signaling networks between different cell types within the tumor and its surrounding stroma. In particular, established tumors are known to stimulate an inflammatory reaction via the secretion of cytokines, chemokines, and growth factors that favor the recruitment of a range of infiltrating immune cell populations into the tumor microenvironment. While potentially able to exert tumor control, this inflammatory reaction is typically seized upon by the tumor to promote its own growth and progression towards metastasis. This review focuses on recent advances in understanding how an established tumor can initiate an inflammatory response via the release of pro-inflammatory mediators, such as IL-6 and IL-8, and their roles in cancer metastasis. In particular, the role of the epithelial-mesenchymal transition (EMT), a phenotypic switch observed in carcinomas that promotes progression towards metastasis, is discussed here in relation to cancer inflammation.
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