IL-1R1 signaling facilitates Munro's microabscess formation in psoriasiform imiquimod-induced skin inflammation.
IL-1R1 signaling facilitates Munro's microabscess formation in psoriasiform imiquimod-induced skin inflammation.
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DOI：
10.1038/jid.2012.512
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发表时间：
2013-06
影响因子：
6.5
通讯作者：
Jensen, Liselotte E.
中科院分区：
文献类型：
--
作者：
Uribe-Herranz, Mireia;Lian, Li-Hua;Hooper, Kirsten M.;Milora, Katelynn A.;Jensen, Liselotte E.
门罗氏微脓肿含有多形核白细胞，在银屑病患者的表皮中形成。中性粒细胞进入表皮的机制尚不清楚。我们利用人类和小鼠原代角质形成细胞培养以及吡喹莫德诱导的银屑病样皮肤炎症小鼠模型，探讨了白细胞介素-1 （IL-1）信号在微脓肿形成中的作用。体外咪喹莫特刺激IL-1α和中性粒细胞募集趋化因子的产生。咪喹莫特激活的趋化因子表达依赖于腺苷信号，不依赖于IL-1α和IL-1受体1型（IL-1R1）；IL-1α可增强咪喹莫特诱导的趋化因子的表达。咪喹莫特在体内局部应用可导致野生型小鼠表皮微脓肿形成、棘皮增生、IL-1α和趋化因子表达升高。然而，在IL-1R1缺乏的小鼠中，这些反应要么不存在，要么显著减少。这些结果表明，IL-1α和IL-1R1信号在咪喹莫特诱导的银屑病样皮肤炎症的微脓肿形成、中性粒细胞募集趋化因子表达和棘层形成中至关重要。
Munro’s microabscesses contain polymorphonuclear leukocytes and form specifically in the epidermis of psoriasis patients. The mechanism whereby the neutrophils are recruited into the epidermis is poorly understood. Using a combination of human and mouse primary keratinocyte cell cultures and the imiquimod-induced psoriasis-like mouse model of skin inflammation we explored the role of interleukin-1 (IL-1) signaling in microabscess formation. In vitro imiquimod stimulated production of IL-1α and neutrophil recruiting chemokines. Imiquimod activated chemokine expression was dependent upon adenosine signaling and independent of IL-1α and IL-1 receptor type 1 (IL-1R1); nevertheless, IL-1α could enhance chemokine expression initiated by imiquimod. Topical application of imiquimod in vivo led to epidermal microabscess formation, acanthosis and increased IL-1α and chemokine expression in the skin of wild type mice. However, in IL-1R1 deficient mice these responses were either absent or dramatically reduced. These results demonstrate that IL-1α and IL-1R1 signaling is essential for microabscess formation, neutrophil recruiting chemokine expression and acanthosis in psoriasis-like skin inflammation induced by imiquimod.
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影响因子：
3.5
作者：
Bowcock, AM;Shannon, W;Menter, A
通讯作者：
Menter, A
DOI：
10.4049/jimmunol.1001538
发表时间：
2010-11-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Tonel G;Conrad C;Laggner U;Di Meglio P;Grys K;McClanahan TK;Blumenschein WM;Qin JZ;Xin H;Oldham E;Kastelein R;Nickoloff BJ;Nestle FO
通讯作者：
Nestle FO
影响因子：
5.4
作者：
Kan, Yuji;Okabayashi, Tamaki;Yamashita, Toshiharu
通讯作者：
Yamashita, Toshiharu
影响因子：
6.5
作者：
Schoen, Michael P.;Schoen, Margarete;Klotz, Karl-Norbert
通讯作者：
Klotz, Karl-Norbert
影响因子：
1.1
作者：
Steffen, C
通讯作者：
Steffen, C