Low Body Weight Increases the Risk of Ischemic Stroke and Major Bleeding in Atrial Fibrillation: The COOL-AF Registry.
Low Body Weight Increases the Risk of Ischemic Stroke and Major Bleeding in Atrial Fibrillation: The COOL-AF Registry.
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DOI：
10.3390/jcm9092713
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发表时间：
2020-08-22
影响因子：
3.9
通讯作者：
Lip GYH
中科院分区：
文献类型：
--
作者：
Krittayaphong R;Chichareon P;Komoltri C;Kornbongkotmas S;Yindeengam A;Lip GYH
我们旨在确定低体重（LBW）状态（<50 kg）是否与泰国非瓣膜性房颤（NVAF）患者缺血性卒中和出血风险增加独立相关。(1)背景：目前尚不清楚LBW是否影响NVAF患者的临床结局。(2)方法：这项前瞻性多中心队列研究纳入了入组COOL-AF登记研究的患者。收集以下数据：人口统计学数据、病史、风险因素和共病状况、实验室和研究数据以及药物。每6个月收集一次随访数据。随访期间的临床事件得到了裁定委员会的确认。(3)结果：共纳入3367例患者。平均年龄为67.2 ± 11.2岁。338例患者（11.3%）存在LBW。分别有75.3%和26.2%的患者使用抗凝剂和抗血小板药物。在25.7个月的随访期间，缺血性卒中、大出血、脑出血（ICH）和死亡的发生率分别为2.9%、4.4%、1.4%和7.7%。LBW是缺血性卒中、大出血、ICH和死亡的独立预测因子，风险比分别为2.40、1.79、2.37和2.65。(4)结论：在泰国NVAF患者中，LBW与不良结局风险增加独立相关。在平衡不同体重患者预防卒中的风险和获益时，应仔细考虑这一点。
We aimed to determine if low body weight (LBW) status (<50 kg) is independently associated with increased risk of ischemic stroke and bleeding in Thai patients with non-valvular atrial fibrillation (NVAF). (1) Background: It has been unclear whether LBW influence clinical outcome of patients with NVAF. (2) Methods: This prospective multicenter cohort study included patients enrolled in the COOL-AF Registry. The following data were collected: demographic data, medical history, risk factors and comorbid conditions, laboratory and investigation data, and medications. Follow-up data were collected every 6 months. Clinical events during follow-up were confirmed by the adjudication committee. (3) Results: A total of 3367 patients were enrolled. The mean age was 67.2 ± 11.2 years. LBW was present in 338 patients (11.3%). Anticoagulant and antiplatelet was prescribed in 75.3% and 26.2% of patients, respectively. Ischemic stroke, major bleeding, intracerebral hemorrhage (ICH), and death occurred during follow-up in 2.9%, 4.4%, 1.4%, and 7.7% of patients, respectively, during 25.7 months follow-up. LBW was an independent predictor of ischemic stroke, major bleeding, ICH, and death, with a hazard ratio of 2.40, 1.79, 2.37, and 2.65, respectively. (4) Conclusions: LBW was independently associated with increased risk of adverse outcomes in Thai patients with NVAF. This should be carefully considered when balancing the risks and benefits of stroke prevention among patients with different body weights.
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DOI：
10.1016/s0735-1097(03)00630-2
发表时间：
2003-07-16
影响因子：
24
作者：
Higashi, Y;Sasaki, S;Yoshizumi, M
通讯作者：
Yoshizumi, M
DOI：
10.11909/j.issn.1671-5411.2016.03.002
发表时间：
2016-03
期刊：
Journal of geriatric cardiology : JGC
影响因子：
--
作者：
Phrommintikul A;Detnuntarat P;Prasertwitayakij N;Wongcharoen W
通讯作者：
Wongcharoen W
影响因子：
2.2
作者：
Kongbunkiat, Kannikar;Kasemsap, Narongrit;Sawanyawisuth, Kittisak
通讯作者：
Sawanyawisuth, Kittisak
影响因子：
6.1
作者：
Kirchhof, Paulus;Benussi, Stefano;Zeppenfeld, Katja
通讯作者：
Zeppenfeld, Katja
影响因子：
8.3
作者：
Chao, Tze-Fan;Lip, Gregory Y. H.;Chen, Shih-Ann
通讯作者：
Chen, Shih-Ann