Characterization of a Tumor-Microenvironment-Relevant Gene Set Based on Tumor Severity in Colon Cancer and Evaluation of Its Potential for Dihydroartemisinin Targeting.
Characterization of a Tumor-Microenvironment-Relevant Gene Set Based on Tumor Severity in Colon Cancer and Evaluation of Its Potential for Dihydroartemisinin Targeting.
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DOI：
10.1155/2021/4812068
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Liu J
中科院分区：
文献类型：
--
作者：
Liang B;Zheng B;Zhou Y;Lai ZQ;Zhang C;Yan Z;Li Z;Li X;Gong P;Qu J;Liu J
结肠癌（COAD）是世界上癌症死亡的主要原因。大多数COAD患者死于癌细胞转移。然而，COAD转移表型的机制尚不清楚。相反，肿瘤微环境（TME）的特定特征可以预测COAD患者的不良结局，包括转移，TME在控制COAD进展中的作用是不可否认的。因此，探索TME在COAD中的作用可能有助于我们更好地了解COAD进展背后的分子机制，从而改善患者的临床结果和质量。在这里，我们确定了一个特定的TME调节网络，包括AEBP1、BGN、POST和FAP (STMERN)，它与COAD患者的临床结果密切相关。我们研究的综合计算机分析显示，STMERN与COAD的严重程度高度相关。同时，我们的研究结果表明STMERN可能与COAD的免疫浸润有关。重要的是，我们发现双氢青蒿素（DHA）可能与STMERN相互作用。我们认为DHA可能通过调节COAD的STMERN参与免疫浸润。综上所述，我们的数据提供了一组COAD进展和预后不良的生物标志物。这些发现可能对COAD的进展具有潜在的预后和治疗意义。
Colon cancer (COAD) is a leading cause of cancer mortality in the world. Most patients with COAD die as a result of cancer cell metastasis. However, the mechanisms underlying the metastatic phenotype of COAD remain unclear. Instead, particular features of the tumor microenvironment (TME) could predict adverse outcomes including metastasis in patients with COAD, and the role of TME in governing COAD progression is undeniable. Therefore, exploring the role of TME in COAD may help us better understand the molecular mechanisms behind COAD progression which may improve clinical outcomes and quality of patients. Here, we identified a Specific TME Regulatory Network including AEBP1, BGN, POST, and FAP (STMERN) that is highly involved in clinical outcomes of patients with COAD. Comprehensive in silico analysis of our study revealed that the STMERN is highly correlated with the severity of COAD. Meanwhile, our results reveal that the STMERN might be associated with immune infiltration in COAD. Importantly, we show that dihydroartemisinin (DHA) potentially interacts with the STMERN. We suggest that DHA might contribute to immune infiltration through regulating the STMERN in COAD. Taken together, our data provide a set of biomarkers of progression and poor prognosis in COAD. These findings could have potential prognostic and therapeutic implications in the progression of COAD.
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