Preoperative Serum Metabolites and Potential Biomarkers for Perioperative Cognitive Decline in Elderly Patients.
Preoperative Serum Metabolites and Potential Biomarkers for Perioperative Cognitive Decline in Elderly Patients.
复制标题
老年患者围术期认知能力下降的术前血清代谢物和潜在生物标志物
DOI：
10.3389/fpsyt.2021.665097
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发表时间：
2021
影响因子：
4.7
通讯作者：
Yu X
中科院分区：
文献类型：
--
作者：
Lu W;Jiang Z;Huang J;Bian J;Yu X
围手术期认知功能下降是老年患者围手术期常见的神经认知障碍之一。虽然POCD增加了患者的死亡率和住院时间，但确切的炎症和相关机制仍不清楚。此外，POCD的诊断缺乏一个统一、直观的神经心理学评价量表。代谢物可以揭示细胞过程留下的化学指纹，这为理解背后的生物过程提供了一个新的方面。根据术后MMSE评分将56例择期骨科手术患者分为POCD组和非POCD组。分析两组术前和术后血清代谢物。然后，我们使用术前样本中的10种差异代谢物作为特征进行SVM模型，以评估患者的POCD风险，这似乎与POCD呈正相关，可能是潜在的生物标志物。我们还分析了POCD患者术前和术后样本的差异血清代谢物。通过分析POCD患者与非POCD患者的重叠差异代谢物，进一步推断出7种与POCD机制正相关的代谢物。我们的研究结果提供了一个更方便的方法，以帮助POCD的诊断和预防使用生物标志物，并探讨背后的可能机制。
Perioperative cognitive decline is one of the perioperative neurocognitive disorders common to see in elderly patients. Although POCD increases patient mortality and hospitalization time, the exact inflammatory and related mechanisms are still unknown. Besides, the diagnosis of POCD lacks a unified and straightforward evaluation neuropsychological scale. Metabolites could reveal chemical fingerprints left behind by the cellular process, which provides a new aspect to understand the biological process behind. According to the post-operative MMSE score, 56 patients who received elective orthopedics surgery were included and divided into POCD and Non-POCD groups. Preoperative serum metabolites in both groups and post-operative serum metabolites were analyzed. We then performed an SVM model using 10 differential metabolites in preoperative samples as features to evaluate the patients' risk of POCD, which appeared to be positively associated with POCD and could be a potential biomarker. We also analyzed differential serum metabolites from preoperative and post-operative samples of POCD patients. By analyzing their overlap differential metabolites with between POCD and Non-POCD patients, we further inferred seven metabolites positively related to the POCD mechanism. Our results provide a more convenient method to aid POCD diagnosis and prevention using biomarkers and explore the possible mechanism behind.
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影响因子：
1.6
作者：
Heo, HJ;Park, YJ;Shin, DH
通讯作者：
Shin, DH
影响因子：
8.8
作者：
Evered, L.;Silbert, B.;Eckenhoff, R. G.
通讯作者：
Eckenhoff, R. G.
影响因子：
3.3
作者：
Xu, Ji-Hong;Zhang, Tie-Zheng;Zhang, Yi-Nan
通讯作者：
Zhang, Yi-Nan
影响因子：
4.8
作者：
Fournier A;Krause R;Winterer G;Schneider R
通讯作者：
Schneider R
DOI：
10.1093/gerona/glx001
发表时间：
2017-12-01
影响因子：
5.1
作者：
Guo, Yong;Zhang, Yinan;Jiang, Wei
通讯作者：
Jiang, Wei