Cyclooxygenase-2: A Role in Cancer Stem Cell Survival and Repopulation of Cancer Cells during Therapy.
Cyclooxygenase-2: A Role in Cancer Stem Cell Survival and Repopulation of Cancer Cells during Therapy.
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DOI：
10.1155/2016/2048731
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发表时间：
2016
影响因子：
4.3
通讯作者：
Argyle DJ
中科院分区：
文献类型：
--
作者：
Pang LY;Hurst EA;Argyle DJ
环氧合酶-2（考克斯-2）是催化前列腺素类化合物（包括前列腺素E2（PGE 2），炎症和血管生成的主要介质）合成的酶的诱导形式。考克斯-2在癌细胞中过表达，并且与进行性肿瘤生长以及癌细胞对常规化疗和放疗的抗性相关。这些疗法通常以多个剂量递送，这些剂量间隔开以允许在治疗之间恢复正常组织。然而，存活的癌细胞在治疗间隔期间也会增殖，导致肿瘤的再增殖并限制治疗的有效性。肿瘤细胞再增殖是治疗失败的主要原因。中心法则是，传统的化疗和放疗选择能够重新启动肿瘤生长的耐药癌细胞。然而，有令人信服的证据表明，由增加的考克斯-2表达和下游PGE 2释放驱动的积极增殖反应，这有助于肿瘤的再增殖和不良的患者结局。在这篇综述中，我们将研究考克斯-2在癌症干细胞生物学中的作用的证据，并作为一种介质的肿瘤再增殖，可以分子靶向克服耐药性治疗。
Cyclooxygenase-2 (COX-2) is an inducible form of the enzyme that catalyses the synthesis of prostanoids, including prostaglandin E2 (PGE2), a major mediator of inflammation and angiogenesis. COX-2 is overexpressed in cancer cells and is associated with progressive tumour growth, as well as resistance of cancer cells to conventional chemotherapy and radiotherapy. These therapies are often delivered in multiple doses, which are spaced out to allow the recovery of normal tissues between treatments. However, surviving cancer cells also proliferate during treatment intervals, leading to repopulation of the tumour and limiting the effectiveness of the treatment. Tumour cell repopulation is a major cause of treatment failure. The central dogma is that conventional chemotherapy and radiotherapy selects resistant cancer cells that are able to reinitiate tumour growth. However, there is compelling evidence of an active proliferative response, driven by increased COX-2 expression and downstream PGE2 release, which contribute to the repopulation of tumours and poor patient outcome. In this review, we will examine the evidence for a role of COX-2 in cancer stem cell biology and as a mediator of tumour repopulation that can be molecularly targeted to overcome resistance to therapy.
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影响因子：
4.7
作者：
Buckman, SY;Gresham, A;Pentland, AP
通讯作者：
Pentland, AP
影响因子：
16.6
作者：
Boodram, Janine N.;Mcgregor, Iain J.;Suntharalingam, Kogularamanan
通讯作者：
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影响因子：
11.8
作者：
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通讯作者：
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影响因子：
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作者：
Buchanan, FG;Wang, DZ;DuBois, RN
通讯作者：
DuBois, RN
DOI：
10.1016/0002-9343(93)90396-7
发表时间：
1993-08-09
期刊：
The American journal of medicine
影响因子：
--
作者：
DeWitt, D L;Meade, E A;Smith, W L
通讯作者：
Smith, W L