STING Signaling in Cancer Cells: Important or Not?
STING Signaling in Cancer Cells: Important or Not?
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DOI：
10.1007/s00005-017-0481-7
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发表时间：
2018-04
影响因子：
3.2
通讯作者：
Nowis D
中科院分区：
文献类型：
--
作者：
Sokolowska O;Nowis D
干扰素基因刺激因子（STING）是一种衔接蛋白，在响应胞质核酸配体激活I型干扰素中起重要作用。最近的证据表明STING途径参与诱导抗肿瘤免疫应答。因此，STING激动剂现在被广泛开发为一类新的癌症治疗剂。然而，关于癌细胞中激活的STING介导的信号传导对抗肿瘤治疗功效的影响知之甚少。已经表明，癌细胞中STING依赖性途径的激活可以导致免疫细胞的肿瘤浸润和抗癌免疫应答的调节。了解STING通路在癌细胞中的功能可能为有效治疗策略的发展提供重要见解。本文综述了STING通路在癌细胞中的作用，这是一个很大程度上未知的话题，最近在STING介导的抗肿瘤反应的背景下变得很重要。
Stimulator of interferon genes (STING) is an adaptor protein that plays an important role in the activation of type I interferons in response to cytosolic nucleic acid ligands. Recent evidence indicates involvement of the STING pathway in the induction of antitumor immune response. Therefore, STING agonists are now being extensively developed as a new class of cancer therapeutics. However, little is known about the consequences of activated STING-mediated signaling in cancer cells on the efficacy of the antitumor treatment. It has been shown that activation of the STING-dependent pathway in cancer cells can result in tumor infiltration with immune cells and modulation of the anticancer immune response. Understanding the function of STING pathway in cancer cells might provide important insights into the development of effective therapeutic strategies. This review focuses on the role of STING pathway in cancer cells, the largely unknown topic that has recently emerged to be important in the context of STING-mediated antitumor responses.
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