Association between amorphous calcium-phosphate ratios in circulating calciprotein particles and prognostic biomarkers in hemodialysis patients.
Association between amorphous calcium-phosphate ratios in circulating calciprotein particles and prognostic biomarkers in hemodialysis patients.
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DOI：
10.1038/s41598-022-17405-7
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发表时间：
2022-07-29
影响因子：
4.6
通讯作者：
Kuro-o, Makoto
中科院分区：
文献类型：
--
作者：
Nakamura, Kimihiko;Isoyama, Naohito;Nakayama, Yuki;Hiroyoshi, Toshiya;Fujikawa, Koki;Miura, Yutaka;Kurosu, Hiroshi;Matsuyama, Hideyasu;Kuro-o, Makoto
钙蛋白颗粒（CPPs）是含有结晶和/或非结晶（无定形）磷酸钙（CaPi）的循环胶体矿物质-蛋白质复合物。血清CPP水平与慢性肾脏病（CKD）患者的血管硬度和钙化相关。体外研究表明，含有结晶CaPi的CPP比不含结晶CaPi的CPP更具动脉硬化性和致炎性。因此，我们假设，不仅数量，而且CPPs（CaPi的相位）的质量可能会影响临床结果。为了验证这一假设，我们定量了无定形CaPi比率，定义为183例血液透析患者血清CPP中无定形CaPi量与总CaPi量的比率，并探讨了其与血液透析患者预后相关的血清参数的可能相关性。多变量分析显示，无定形CaPi比率与血红蛋白呈正相关，与成纤维细胞生长因子-21（FGF 21）呈负相关，在调整总CaPi量后仍显着。由于低血红蛋白和高FGF 21与死亡率增加相关，因此本研究需要进一步研究以确定循环CPP中低无定形CaPi比率是否与血液透析患者的不良预后相关。
Calciprotein particles (CPPs) are circulating colloidal mineral-protein complexes containing crystalline and/or non-crystalline (amorphous) calcium-phosphate (CaPi). Serum CPP levels correlate with vascular stiffness and calcification in patients with chronic kidney disease (CKD). In vitro studies showed that CPPs containing crystalline CaPi were more arteriosclerogenic and inflammogenic than CPPs without containing crystalline CaPi. Thus, we hypothesized that not only the quantity but also the quality of CPPs (the phase of CaPi) might affect clinical outcomes. To test this hypothesis, we quantified amorphous CaPi ratio defined as the ratio of the amorphous CaPi amount to the total CaPi amount in serum CPPs from 183 hemodialysis patients and explored its possible correlation with serum parameters associated with prognosis of hemodialysis patients. Multivariate analysis revealed that the amorphous CaPi ratio correlated positively with hemoglobin and negatively with fibroblast growth factor-21 (FGF21), which remained significant after adjusting for the total CaPi amount. Because low hemoglobin and high FGF21 are associated with increased mortality, the present study warrants further studies to determine whether low amorphous CaPi ratio in circulating CPPs may be associated with poor prognosis in hemodialysis patients.
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DOI：
10.1073/pnas.0701600104
发表时间：
2007-05-01
影响因子：
11.1
作者：
Ogawa, Yasushi;Kurosu, Hiroshi;Kuro-o, Makoto
通讯作者：
Kuro-o, Makoto
影响因子：
3.7
作者：
Lin Z;Zhou Z;Liu Y;Gong Q;Yan X;Xiao J;Wang X;Lin S;Feng W;Li X
通讯作者：
Li X
DOI：
10.1056/nejmoa0706130
发表时间：
2008-08-07
期刊：
The New England journal of medicine
影响因子：
--
作者：
Gutiérrez OM;Mannstadt M;Isakova T;Rauh-Hain JA;Tamez H;Shah A;Smith K;Lee H;Thadhani R;Jüppner H;Wolf M
通讯作者：
Wolf M
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
4.8
作者：
Heiss, A;DuChesne, A;Jahnen-Dechent, W
通讯作者：
Jahnen-Dechent, W