Circulating FGF21 levels are progressively increased from the early to end stages of chronic kidney diseases and are associated with renal function in Chinese.
Circulating FGF21 levels are progressively increased from the early to end stages of chronic kidney diseases and are associated with renal function in Chinese.
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DOI：
10.1371/journal.pone.0018398
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发表时间：
2011-04-15
期刊：
影响因子：
3.7
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Lin Z;Zhou Z;Liu Y;Gong Q;Yan X;Xiao J;Wang X;Lin S;Feng W;Li X
成纤维细胞生长因子21 （FGF21）是一种肝脏激素，参与调节脂质和碳水化合物代谢。本研究旨在验证FGF21浓度升高与慢性肾脏疾病（CKD）进展不同阶段肾功能改变和左心室肥厚（LVH）存在相关的假设。共招募240名受试者，包括200名CKD患者（146名门诊患者，54名长期血液透析患者）和40名健康对照者。所有CKD受试者均接受超声心动图评估左心室质量指数。所有受试者血浆FGF21水平及其他临床生化参数均按标准临床检查方法测定。血浆FGF21水平随CKD早期和终末期的发展而显著升高（趋势P<0.001），且CKD患者的FGF21水平显著高于健康者（P<0.001）。伴有LVH的CKD患者血浆FGF21水平高于无LVH的患者（P = 0.001）。此外，血浆FGF21水平与肌酐、血尿素氮（BUN）、β2微球蛋白、收缩压、脂联素、磷酸盐、蛋白尿、CRP和甘油三酯呈正相关，而与肌酐清除率（CCR）、估计肾小球滤液率（eGFR）、HDL-c、LDL-c、白蛋白和LVH负相关，在调整BMI、性别、年龄和是否患有糖尿病后。多元逐步回归分析显示，FGF21与BUN、Phosphate、LVMI、β2微球蛋白独立相关（均P<0.05）。血浆FGF21水平随着早期至终末期CKD的发展而显著升高，并且在中国人群中与肾功能和不良脂质谱独立相关。了解FGF21升高是否与CKD心肌肥厚相关，需要进一步研究。
Fibroblast growth factor 21 (FGF21) is a hepatic hormone involved in the regulation of lipid and carbohydrate metabolism. This study aims to test the hypothesis that elevated FGF21 concentrations are associated with the change of renal function and the presence of left ventricular hypertrophy (LVH) in the different stages of chronic kidney disease (CKD) progression. 240 subjects including 200 CKD patients (146 outpatients and 54 long-term hemodialytic patients) and 40 healthy control subjects were recruited. All CKD subjects underwent echocardiograms to assess left ventricular mass index. Plasma FGF21 levels and other clinical and biochemical parameters in all subjects were obtained based on standard clinical examination methods. Plasma FGF21 levels were significantly increased with the development of CKD from early- and end-stage (P<0.001 for trend), and significantly higher in CKD subjects than those in healthy subjects (P<0.001). Plasma FGF21 levels in CKD patients with LVH were higher than those in patients without LVH (P = 0.001). Furthermore, plasma FGF21 level correlated positively with creatinine, blood urea nitrogen (BUN), β2 microglobulin, systolic pressure, adiponectin, phosphate, proteinuria, CRP and triglyceride, but negatively with creatinine clearance rate (CCR), estimated glomerular filtrate rate (eGFR), HDL-c, LDL-c, albumin and LVH after adjusting for BMI, gender, age and the presence of diabetes mellitus. Multiple stepwise regression analyses indicated that FGF21 was independently associated with BUN, Phosphate, LVMI and β2 microglobulin (all P<0.05). Plasma FGF21 levels are significantly increased with the development of early- to end-stage CKD and are independently associated with renal function and adverse lipid profiles in Chinese population. Understanding whether increased FGF21 is associated with myocardial hypertrophy in CKD requires further study.
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影响因子：
3.7
作者：
Lin Z;Wu Z;Yin X;Liu Y;Yan X;Lin S;Xiao J;Wang X;Feng W;Li X
通讯作者：
Li X
DOI：
10.1056/nejmoa0706130
发表时间：
2008-08-07
期刊：
The New England journal of medicine
影响因子：
--
作者：
Gutiérrez OM;Mannstadt M;Isakova T;Rauh-Hain JA;Tamez H;Shah A;Smith K;Lee H;Thadhani R;Jüppner H;Wolf M
通讯作者：
Wolf M
DOI：
10.1038/nrd2792
发表时间：
2009-03
期刊：
Nature reviews. Drug discovery
影响因子：
--
作者：
通讯作者：
--
影响因子：
29
作者：
Badman, Michael K.;Pissios, Pavlos;Maratos-Flier, Eleftheria
通讯作者：
Maratos-Flier, Eleftheria
影响因子：
120.7
作者：
Coresh, Josef;Selvin, Elizabeth;Levey, Andrew S.
通讯作者：
Levey, Andrew S.