Proinflammatory cytokines are associated with prolonged viral RNA shedding in COVID-19 patients.
Proinflammatory cytokines are associated with prolonged viral RNA shedding in COVID-19 patients.
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DOI：
10.1016/j.clim.2020.108611
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Zhang S
中科院分区：
文献类型：
--
作者：
Gao C;Zhu L;Jin CC;Tong YX;Xiao AT;Zhang S
自2019年12月以来，冠状病毒病2019(新冠肺炎)以全球大流行的形式出现。我们的目的是调查该病的临床特点，并分析病毒RNA长时间脱落的危险因素。我们回顾性地收集了在武汉的一个中心住院的112名新冠肺炎患者的数据，中国。对病毒脱落期延长(≥28天)的相关因素进行了研究。49例(43.8%)患者出现病毒RNA长时间脱落。病毒排出时间延长的患者年龄较大，高血压患病率较高。IL-2R和肿瘤坏死因子-α等促炎细胞因子在病毒脱毒时间延长的患者中显著升高。多因素分析显示，高血压、高龄、淋巴细胞减少和血清IL-2R升高是病毒长时间脱落的独立危险因素。这项全面的调查揭示了有或没有病毒RNA长时间脱落的患者的明显特征。高血压、老年、淋巴细胞减少和高水平的促炎细胞因子可能与病毒的长时间脱落有关。
Since December 2019, Coronavirus Disease 2019 (COVID-19) has emerged as a global pandemic. We aimed to investigate the clinical characteristics and analyzed the risk factors for prolonged viral RNA shedding. We retrospectively collected data from 112 hospitalized COVID-19 patients in a single center in Wuhan, China. Factors associated with prolonged viral RNA shedding (≥28 days) were investigated. Forty-nine (43.8%) patients had prolonged viral RNA shedding. Patients with prolonged viral shedding were older and had a higher rate of hypertension. Proinflammatory cytokines, including interleukin-2R (IL-2R) and tumor necrosis factor-α (TNF-α), were significantly elevated in patients with prolonged viral shedding. Multivariate analysis revealed that hypertension, older age, lymphopenia and elevated serum IL-2R were independent risk factors for prolonged viral shedding. This comprehensive investigation revealed the distinct characteristics between patients with or without prolonged viral RNA shedding. Hypertension, older age, lymphopenia and high levels of proinflammatory cytokines may be correlated with prolonged viral shedding.
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