Survival of exfoliated epithelial cells: a delicate balance between anoikis and apoptosis.
Survival of exfoliated epithelial cells: a delicate balance between anoikis and apoptosis.
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DOI：
10.1155/2011/534139
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发表时间：
2011
影响因子：
--
通讯作者：
Bertrand K
中科院分区：
文献类型：
--
作者：
Bertrand K
从生物体液中回收脱落细胞是一种非侵入性技术，在转化研究领域有着很高的需求。脱落的上皮细胞可以从几种体液（即母乳、尿液和消化液）中分离出来，作为细胞混合物（衰老细胞、凋亡细胞、增殖细胞或静止细胞）。最有趣的是静止细胞，它可以用来获得原代培养，表明一些表型保留克隆潜能。这种脱落的细胞被认为在脱落后迅速进入黑色素瘤。Anoikis可以被认为是上皮细胞在及时失去与细胞外基质和细胞邻居的接触后促进细胞存活的自噬状态。本文介绍了目前对脱落的理解以及方法对分离的胃肠道上皮细胞类型的影响，最后推测了脱落和凋亡之间的平衡，以解释胃肠道上皮细胞在环境中的存活。
The recovery of exfoliated cells from biological fluids is a noninvasive technology which is in high demand in the field of translational research. Exfoliated epithelial cells can be isolated from several body fluids (i.e., breast milk, urines, and digestives fluids) as a cellular mixture (senescent, apoptotic, proliferative, or quiescent cells). The most intriguing are quiescent cells which can be used to derive primary cultures indicating that some phenotypes retain clonogenic potentials. Such exfoliated cells are believed to enter rapidly in anoikis after exfoliation. Anoikis can be considered as an autophagic state promoting epithelial cell survival after a timely loss of contact with extracellular matrix and cell neighbors. This paper presents current understanding of exfoliation along with the influence of methodology on the type of gastrointestinal epithelial cells isolated and, finally, speculates on the balance between anoikis and apoptosis to explain the survival of gastrointestinal epithelial cells in the environment.
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影响因子：
64.8
作者：
Alenghat, Theresa;Meyers, Katherine;Mullican, Shannon E.;Leitner, Kirstin;Adeniji-Adele, Adetoun;Avila, Jacqueline;Bucan, Maja;Ahima, Rexford S.;Kaestner, Klaus H.;Lazar, Mitchell A.
通讯作者：
Lazar, Mitchell A.
影响因子：
1.8
作者：
Chen, An
通讯作者：
Chen, An
影响因子：
2.8
作者：
HAUS E;LAKATUA D J;WHITE M
通讯作者：
WHITE M
影响因子：
29.4
作者：
BUCHI, KN;MOORE, JG;RUBIN, NH
通讯作者：
RUBIN, NH
影响因子：
4.8
作者：
BLOMMAART, EFC;LUIKEN, JJFP;MEIJER, AJ
通讯作者：
MEIJER, AJ