Molecular biology of drug resistance in Mycobacterium tuberculosis.
Molecular biology of drug resistance in Mycobacterium tuberculosis.
复制标题
DOI：
10.1007/82_2012_279
复制
发表时间：
2013
影响因子：
--
通讯作者：
Liem Nguyen
中科院分区：
文献类型：
--
作者：
Smith, Tasha;Wolff, Kerstin A.;Liem Nguyen
由于抗生素的发现，结核病已成为一种可治愈的疾病。然而，它仍然是最难治疗的感染之一。目前的大多数结核病治疗方案包括每天服用四种对患者有剧毒的药物六到九个月。这些漫长治疗的目的是彻底根除结核分枝杆菌，以其抵抗大多数抗菌剂的能力而闻名，从而防止耐药突变体的形成。相反，长期治疗导致患者依从性差。这一点，再加上药物选择的严重限制，导致了对少数可用抗生素的耐药性越来越强的菌株的出现。在这里，我们回顾了我们目前对M的深刻耐药的分子机制的理解。结核这些知识对于开发更有效的抗生素至关重要，这些抗生素不仅对耐药M。此外，它还有助于缩短目前对药物敏感的结核病所需的治疗疗程。
Tuberculosis (TB) has become a curable disease thanks to the discovery of antibiotics. However, it has remained one of the most difficult infections to treat. Most current TB regimens consist of six to nine months of daily doses of four drugs that are highly toxic to patients. The purpose of these lengthy treatments is to completely eradicate Mycobacterium tuberculosis, notorious for its ability to resist most antibacterial agents, thereby preventing the formation of drug resistant mutants. On the contrary, the prolonged therapies have led to poor patient adherence. This, together with a severe limit of drug choices, has resulted in the emergence of strains that are increasingly resistant to the few available antibiotics. Here we review our current understanding of molecular mechanisms underlying the profound drug resistance of M. tuberculosis. This knowledge is essential for the development of more effective antibiotics that not only are potent against drug resistant M. tuberculosis strains but also help shorten the current treatment courses required for drug susceptible TB.
登录
查看更多内容
影响因子：
30.8
作者：
Comas, Inaki;Borrell, Sonia;Roetzer, Andreas;Rose, Graham;Malla, Bijaya;Kato-Maeda, Midori;Galagan, James;Niemann, Stefan;Gagneux, Sebastien
通讯作者：
Gagneux, Sebastien
DOI：
10.1016/j.bbapap.2009.09.008
发表时间：
2010-03-01
影响因子：
3.2
作者：
Chao, Joseph;Wong, Dennis;Av-Gay, Yossef
通讯作者：
Av-Gay, Yossef
影响因子：
4.9
作者：
Buriánková, K;Doucet-Populaire, F;Pernodet, JL
通讯作者：
Pernodet, JL
由巨噬细胞诱导的外排机制介导的复制分枝杆菌的药物耐受性。
影响因子：
64.5
作者：
Adams KN;Takaki K;Connolly LE;Wiedenhoft H;Winglee K;Humbert O;Edelstein PH;Cosma CL;Ramakrishnan L
通讯作者：
Ramakrishnan L
结核分枝杆菌中，组蛋白样LSR2对多药耐受性和抗生素诱导的反应的转录调节。
影响因子：
6.7
作者：
Colangeli, Roberto;Helb, Danica;Vilcheze, Catherine;Hazbon, Manzour Hernando;Lee, Chee-Gun;Safi, Hassan;Sayers, Brendan;Sardone, Irene;Jones, Marcus B;Fleischmann, Robert D;Peterson, Scott N;Jacobs, William R Jr;Alland, David
通讯作者：
Alland, David