Epigenetics and Genetics of Viral Latency.

Epigenetics and Genetics of Viral Latency.
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DOI:
10.1016/j.chom.2016.04.008
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发表时间:
2016-05-11
影响因子:
30.3
通讯作者:
Lieberman PM
Lieberman PM
中科院分区:
医学1区
文献类型:
--
作者:
Lieberman PM

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病毒潜伏期可以被认为是一种亚稳态的非生产性感染状态,能够随后重新激活以重复感染周期。病毒潜伏感染有许多相关的病理,包括癌症、出生缺陷、神经病变、心血管疾病、慢性炎症和免疫功能障碍。在不同的病毒科、物种和毒株中,控制潜伏期的建立、维持和重新激活的机制是复杂和多样的。然而,正如本综述所述,潜伏病毒感染的共同特性可以被定义。根除潜伏病毒已成为一项重要但难以捉摸的挑战,需要对控制这些过程的机制有更全面的了解。
Viral latency can be considered a metastable, nonproductive infection state that is capable of subsequent reactivation to repeat the infection cycle. Viral latent infections have numerous associated pathologies, including cancer, birth defects, neuropathy, cardiovascular disease, chronic inflammation, and immunological dysfunctions. The mechanisms controlling the establishment, maintenance, and reactivation from latency are complex and diversified among virus families, species, and strains. Yet, as examined in this review, common properties of latent viral infections can be defined. Eradicating latent virus has become an important but elusive challenge and will require a more complete understanding of the mechanisms controlling these processes.
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