Epigenetics and Genetics of Viral Latency.
Epigenetics and Genetics of Viral Latency.
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DOI:
10.1016/j.chom.2016.04.008
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发表时间:
2016-05-11
影响因子:
30.3
通讯作者:
Lieberman PM
中科院分区:
文献类型:
--
作者:
Lieberman PM
Viral latency can be considered a metastable, nonproductive infection state that is capable of subsequent reactivation to repeat the infection cycle. Viral latent infections have numerous associated pathologies, including cancer, birth defects, neuropathy, cardiovascular disease, chronic inflammation, and immunological dysfunctions. The mechanisms controlling the establishment, maintenance, and reactivation from latency are complex and diversified among virus families, species, and strains. Yet, as examined in this review, common properties of latent viral infections can be defined. Eradicating latent virus has become an important but elusive challenge and will require a more complete understanding of the mechanisms controlling these processes.
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