On the crawling of cells.

On the crawling of cells.
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关于细胞的爬行。

DOI:
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发表时间:
1984
期刊:
Journal of embryology and experimental morphology
影响因子:
--
通讯作者:
G. Oster
G. Oster
中科院分区:
--
文献类型:
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作者:
G. Oster

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在体外运动的运动细胞通过一个特征性的运动附属物--片足(lamellipod)来运动,片足是细胞质的一个宽而平的区域,延伸到运动细胞的前面,并且没有细胞器。我在这里描述了一个机械化学模型如何板足推进细胞前进。片层伸展的推进力来自片足内细胞凝胶的膨胀压力。离子条件的局部变化--由领先的膜泄漏引起--激活了隔离因子,这打破了凝胶渗透压和弹性之间的平衡。随后,再收缩和收缩将细胞向前拉。该模型是根据不同阵列的细胞运动的实验观察,并提出了一个共同的物理机制的各种细胞运动现象。
Motile cells moving in vitro do so via a characteristic motile appendage, the lamellipod, a broad, flat region of the cell cytoplasm which extends ahead of the moving cell, and which is devoid of organelles. I describe here a mechanochemical model for how the lamellipod propels the cell forward. The propulsive force for the spreading of the lamella derives from the swelling pressure of the cytogel within the lamellipod. A local change in ionic conditions - caused by a leak through the leading membrane - activates solating factors, which upsets the equilibrium between the gel osmotic pressure and its elasticity. Subsequently, regelling and contraction pull the cell forward. The model is in accordance with a diverse array of experimental observations on cell motility, and suggests a common physical mechanism underlying a variety of cell motility phenomena.
原生动物形成过程中白细胞的连续力学模型。
DOI: 10.1115/1.3138448
发表时间: 1984
期刊: Journal of biomechanical engineering
影响因子: --
作者:
Schmid-Schönbein,GW;Skalak,R
通讯作者: Skalak,R
DOI: 10.1126/science.6266014
发表时间: 1981-08
期刊: Science
影响因子: 56.9
作者:
R. Snyderman;E. Goetzl
通讯作者: R. Snyderman;E. Goetzl
DOI: 10.1371/journal.pcbi.1002112
发表时间: 2011-08
影响因子: 4.3
作者:
Malandrino A;Noailly J;Lacroix D
通讯作者: Lacroix D