Reading without the left ventral occipito-temporal cortex.
Reading without the left ventral occipito-temporal cortex.
复制标题
DOI：
10.1016/j.neuropsychologia.2012.09.030
复制
发表时间：
2012-12
期刊：
影响因子：
2.6
通讯作者：
Price CJ
中科院分区：
文献类型：
--
作者：
Seghier ML;Neufeld NH;Zeidman P;Leff AP;Mechelli A;Nagendran A;Riddoch JM;Humphreys GW;Price CJ
左腹侧枕颞皮层（LvOT）被认为对熟练阅读所需的快速平行字母处理至关重要。在这里，我们研究了熟练读者的快速书面单词识别是否可以通过不涉及LvOT的神经通路来支持。假设来自于一个中风患者，他在广泛的LvOT损伤后获得了阅读障碍。患者的阅读轨迹与纯粹的失读症相关，随着单词长度的增加，重新获得了大声朗读许多单词的能力，但表现却在下降。使用功能性MRI和动态因果模型（DCM），我们发现，当短的（三到五个字母）熟悉的单词被成功阅读时，患者枕叶皮层的视觉输入通过左侧颞上沟（STS）中央部分的活动连接到左侧运动和前运动区域。因此，患者分析暗示左半球“无lvot阅读”通路涉及STS。然后，我们调查了是否可以在29名熟练读者中识别出相同的无LvOT阅读途径，以及熟练阅读参与LvOT的程度是否存在主体间差异。我们发现，在LvOT通路功能连通性最弱的个体中，无LvOT阅读通路的功能连通性最强。这一观察结果证实了我们患者案例研究的结果。我们的研究结果强调了左半球阅读通路的作用，该通路在快速识别熟悉的短书面单词时被激活，特别是在LvOT不参与的情况下。这一通路的保存和使用可能解释了当LvOT受损时，患者如何仍然能够准确地阅读短单词。左枕颞叶皮层受损后，单词阅读也能成功。这是通过左侧颞上沟的另一条通路实现的。►连通性分析表明，正常读者也存在这一通路。我们假设这条通路整合了语义学和音韵学。我们的工作强调了绘制替代性退化阅读路径的重要性。
The left ventral occipito-temporal cortex (LvOT) is thought to be essential for the rapid parallel letter processing that is required for skilled reading. Here we investigate whether rapid written word identification in skilled readers can be supported by neural pathways that do not involve LvOT. Hypotheses were derived from a stroke patient who acquired dyslexia following extensive LvOT damage. The patient followed a reading trajectory typical of that associated with pure alexia, re-gaining the ability to read aloud many words with declining performance as the length of words increased. Using functional MRI and dynamic causal modelling (DCM), we found that, when short (three to five letter) familiar words were read successfully, visual inputs to the patient’s occipital cortex were connected to left motor and premotor regions via activity in a central part of the left superior temporal sulcus (STS). The patient analysis therefore implied a left hemisphere “reading-without-LvOT” pathway that involved STS. We then investigated whether the same reading-without-LvOT pathway could be identified in 29 skilled readers and whether there was inter-subject variability in the degree to which skilled reading engaged LvOT. We found that functional connectivity in the reading-without-LvOT pathway was strongest in individuals who had the weakest functional connectivity in the LvOT pathway. This observation validates the findings of our patient’s case study. Our findings highlight the contribution of a left hemisphere reading pathway that is activated during the rapid identification of short familiar written words, particularly when LvOT is not involved. Preservation and use of this pathway may explain how patients are still able to read short words accurately when LvOT has been damaged. ► Word reading can succeed after damage to the left occipito-temporal cortex. ► This is enabled by an alternative pathway via the left superior temporal sulcus. ► Connectivity analysis demonstrated the existence of this pathway in normal readers. ► We hypothesise that this pathway integrates semantics with phonology. ► Our work stresses the importance of mapping alternative degenerate reading pathways.
登录
查看更多内容
影响因子：
2.5
作者：
Abutalebi, Jubin;Della Rosa, Pasquale Anthony;Cappa, Stefano F.
通讯作者：
Cappa, Stefano F.
影响因子：
0.8
作者：
Cappelletti, M.;Leff, A. P.;Price, C. J.
通讯作者：
Price, C. J.
影响因子：
5.7
作者：
Acs, Ferenc;Greenlee, Mark W.
通讯作者：
Greenlee, Mark W.
影响因子：
14.5
作者：
COSLETT, HB;SAFFRAN, EM;SCHWARTZ, H
通讯作者：
SCHWARTZ, H
影响因子：
3.6
作者：
Epelbaum, Stephane;Pinel, Philippe;Cohen, Laurent
通讯作者：
Cohen, Laurent