Control of microRNA biogenesis by TGFbeta signaling pathway-A novel role of Smads in the nucleus.
Control of microRNA biogenesis by TGFbeta signaling pathway-A novel role of Smads in the nucleus.
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DOI：
10.1016/j.cytogfr.2009.10.004
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发表时间：
2009-10
影响因子：
13
通讯作者：
Davis, Brandi N.
中科院分区：
文献类型：
--
作者：
Hata, Akiko;Davis, Brandi N.
microRNA（miRNAs）是一类小的非编码RNA，通过抑制靶基因来调节多种生物学功能。miRNA谱研究表明，miRNA的水平在正常发育和各种疾病（包括癌症和心血管疾病）的发病过程中发生变化。然而，控制miRNA生物合成的信号通路和调控机制还不清楚。转录后，成熟的miRNA通过一系列由大蛋白复合物介导的协调加工事件产生。我们最近发现转化生长因子β（TGFβ）信号转导通路的信号转导子Smads在细胞核中对miRNA的加工起调节作用。本文就TGFβ信号通路对miRNA生物合成调控的研究进展作一综述。
microRNAs (miRNAs) are small, non-coding RNAs that modulate diverse biological functions through the repression of target genes. miRNA profiling studies have indicated that the levels of miRNAs are altered during normal development and pathogenesis of various diseases, including cancer and cardiovascular disorders. The signaling pathways which control miRNA biogenesis and the mechanisms of regulation, however, are not well understood. Following transcription, mature miRNAs are generated through a series of coordinated processing events mediated by large protein complexes. We recently found that signal transducers of the Transforming Growth Factor β (TGFβ) signaling pathway, the Smads, play a regulatory role in the processing of miRNA in the nucleus. In this review, we summarize the current understanding of the regulation of miRNA biogenesis mediated by the TGFβ signaling pathway.
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