The quasispecies nature and biological implications of the hepatitis C virus.

The quasispecies nature and biological implications of the hepatitis C virus.
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DOI:
10.1016/j.meegid.2009.07.011
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发表时间:
2009-12
影响因子:
3.2
通讯作者:
Branch, Andrea D.
Branch, Andrea D.
中科院分区:
医学3区
文献类型:
--
作者:
Fishman, Sarah L.;Branch, Andrea D.

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许多RNA病毒以一团紧密相关的序列变体的形式存在,称为准种,而不是一群相同的克隆。本文阐述了RNA病毒基因组的准种性质,简要介绍了准种动力学原理及其与经典群体遗传学的区别。然后,我们讨论了准种分析的当前方法,并总结了这种现象的生物学意义,重点是丙型肝炎病毒。
Many RNA viruses exist as a cloud of closely related sequence variants called a quasispecies, rather than as a population of identical clones. In this article, we explain the quasispecies nature of RNA viral genomes, and briefly review the principles of quasispecies dynamics and the differences with classical population genetics. We then discuss the current methods for quasispecies analysis and conclude with the biological implications of this phenomenon, focusing on the hepatitis C virus.
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