The quasispecies nature and biological implications of the hepatitis C virus.
The quasispecies nature and biological implications of the hepatitis C virus.
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DOI:
10.1016/j.meegid.2009.07.011
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发表时间:
2009-12
影响因子:
3.2
通讯作者:
Branch, Andrea D.
中科院分区:
文献类型:
--
作者:
Fishman, Sarah L.;Branch, Andrea D.
关键词:
Many RNA viruses exist as a cloud of closely related sequence variants called a quasispecies, rather than as a population of identical clones. In this article, we explain the quasispecies nature of RNA viral genomes, and briefly review the principles of quasispecies dynamics and the differences with classical population genetics. We then discuss the current methods for quasispecies analysis and conclude with the biological implications of this phenomenon, focusing on the hepatitis C virus.
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