The impact of local therapies for breast cancer on shoulder muscle health and function.
The impact of local therapies for breast cancer on shoulder muscle health and function.
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DOI：
10.1016/j.critrevonc.2022.103759
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发表时间：
2022-09
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
乳腺癌治疗的进步提高了患者的生存率，但也产生了肩部发病等并发症，影响了患者的生活质量。乳腺癌的局部治疗通过改变肌肉微环境、宏观肌肉形态和神经肌肉功能来影响肩部肌肉健康。我们的研究结果表明手术和放射治疗都会损害肩部肌肉组织的健康功能。乳房切除术和乳房切除术后乳房重建通过肌肉形态和神经肌肉功能改变直接影响肩部功能。放射治疗会损害卫星细胞和肌细胞，导致治疗期间和康复后数年细胞死亡。这种损害创造了一个限制其防止萎缩能力的环境。然而，迄今为止的研究仅限于少量实验群体的少量分析，并且缺乏对协变量的控制。未来的研究若要揭示乳腺癌治疗后肩部发病的病理生理机制，必须将肩部肌肉健康和肩部功能的测量结合起来。
Advances in breast cancer treatment have improved patient survival but have also created complications, such as shoulder morbidity, impacting the patient’s quality of life. Local therapies for breast cancer influence shoulder muscle health through changes to the muscular microenvironment, macroscopic muscle morphology, and neuromuscular function.Our findings suggest both surgery and radiation therapy compromise the healthy functioning of shoulder musculature. Mastectomy and post-mastectomy breast reconstruction directly affect shoulder function through muscle morphology and neuromuscular function alterations. Radiation therapy damages satellite cells and myocytes, causing cell death both during treatment and years after recovery. This damage creates an environment limited in its ability to prevent atrophy. However, research to date is limited to a small number of analyses with small experimental populations and a lack of control for covariates. Future research to uncover the pathophysiological mechanisms underlying shoulder morbidity after breast cancer treatment must integrate measures of shoulder muscle health and shoulder function.
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影响因子：
3.1
作者：
Hojris, I;Andersen, J;Overgaard, J
通讯作者：
Overgaard, J
DOI：
10.2519/jospt.2005.35.4.227
发表时间：
2005-04-01
影响因子：
6.1
作者：
Borstad, JD;Ludewig, PM
通讯作者：
Ludewig, PM
影响因子：
18.4
作者：
Hegedus, Eric J.
通讯作者：
Hegedus, Eric J.
影响因子：
1.5
作者：
Hage, J. Joris;van der Heeden, Jorine F.;Veeger, H. E. J.
通讯作者：
Veeger, H. E. J.
影响因子：
6.2
作者：
Gerber, Lynn H.;Stout, Nicole L.;Stricker, Carrie T.
通讯作者：
Stricker, Carrie T.