Hazards in subgroups of human obesity
Hazards in subgroups of human obesity
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人类肥胖亚组的危害
DOI：
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发表时间：
1984
影响因子：
5.5
通讯作者：
P. Björntorp
中科院分区：
文献类型：
--
作者：
P. Björntorp
有许多观察结果表明，人类肥胖症不是一个同质的实体，例如dCbut时的年龄变化，与糖尿病和其他并发症的关系，治疗的预后，扩大的脂肪库的分布，仅举一些例子。这一领域的研究进展似乎受到了严重阻碍，因为我们无法清楚地描述和识别人类肥胖的亚群。虽然肥胖症的治疗仍在等待从通过减少饮食和增加运动来产生持久的负能量平衡的严重方式中取得突破，但人类肥胖症的亚组对于治疗、预防的适应症可能是重要的，并且也许最重要的是，对于理解糖尿病、糖尿病和糖尿病的许多潜在危险的相关并发症的发病机制可能是重要的。高血压和高血脂是最常见的。美国国立卫生研究院强调了这个问题的重要性，最近安排了一次专题讨论会（波基普西，纽约，1980年），开始对这个问题进行研究。最近的工作一直集中在人类肥胖症的脂肪组织及其异质性。很少有证据表明，脂肪组织中的主要功能细胞脂肪细胞存在原发性功能障碍。尽管如此，这可能是一条通往更好理解的途径，类似于血液学家很久以前使用的方法。红细胞在恶性贫血、铁缺乏症和镰状细胞性贫血中并不是主要的致病细胞，但对这种细胞的研究导致了这些疾病的病因学的澄清，并使其得到了适当的临床处理。
There are numerous observations suggesting that human obesity is not a homogenous entity, such as variations in age at dCbut, relationship to diabetes mellitus and other complicating diseases, prognosis of treatment, distribution of the enlarged fat depots, to mention only some examples. It seems likely that progress in research in this area is severely hampered by the fact that we have not been able to clearly characterize and recognize such subgroups of human obesity. Although treatment of obesity is still awaiting a breakthrough from the severe way of creating a long-lasting negative energy balance by decreasing eating and increasing exercise, subgrouping of human obesity might be of importance for the indications for treatment, prevention, and, perhaps most importantly, to understand the pathogenesis of the numerous, potentially dangerous associating complications of which diabetes mellitus, hypertension and hyperlipidaemia are the most common. The importance of this question is stressed by the fact that the National Institutes of Health in the U.S., recently arranged a symposium (Poughkeepsie, New York, 1980) where studies on this question were initiated. Recent work has been focussed on the enlarged adipose tissue and its heterogenicity in human obesity. There is very little evidence, if any, that there is a primary malfunction in the main functional cell in adipose tissue, the adipocyte. Nevertheless, this might be an avenue towards a better understanding, similar to that used by haematologists long ago. The erythrocyte is not primarily sick in pernicious anaemia, sideropenia and sickle-cell anaemia, but studying this cell led to clearing up the aetiology of these diseases and their adequate clinical handling.
影响因子：
5.8
作者：
EVANS, DJ;HOFFMANN, RG;KISSEBAH, AH
通讯作者：
KISSEBAH, AH