The Missing Pieces: The Role of Secretion Systems in Campylobacter jejuni Virulence.
The Missing Pieces: The Role of Secretion Systems in Campylobacter jejuni Virulence.
复制标题
缺失的部分：分泌系统在空肠弯曲杆菌毒力中的作用。
DOI：
10.3390/biom13010135
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发表时间：
2023-01-09
期刊：
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
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作者：
Campylobacter jejuni is likely the most common bacterial cause of gastroenteritis worldwide, responsible for millions of cases of inflammatory diarrhea characterized by severe abdominal cramps and blood in the stool. Further, C. jejuni infections are associated with post-infection sequelae in developed countries and malnutrition and growth-stunting in low- and middle-income countries. Despite the increasing prevalence of the disease, campylobacteriosis, and the recognition that this pathogen is a serious health threat, our understanding of C. jejuni pathogenesis remains incomplete. In this review, we focus on the Campylobacter secretion systems proposed to contribute to host-cell interactions and survival in the host. Moreover, we have applied a genomics approach to defining the structural and mechanistic features of C. jejuni type III, IV, and VI secretion systems. Special attention is focused on the flagellar type III secretion system and the prediction of putative effectors, given that the proteins exported via this system are essential for host cell invasion and the inflammatory response. We conclude that C. jejuni does not possess a type IV secretion system and relies on the type III and type VI secretion systems to establish a niche and potentiate disease.
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影响因子：
4.5
作者：
Brunet YR;Zoued A;Boyer F;Douzi B;Cascales E
通讯作者：
Cascales E
影响因子：
4.4
作者：
Baig A;McNally A;Dunn S;Paszkiewicz KH;Corander J;Manning G
通讯作者：
Manning G
DOI：
10.1093/cid/ciw542
发表时间：
2016-11-01
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Amour C;Gratz J;Mduma E;Svensen E;Rogawski ET;McGrath M;Seidman JC;McCormick BJ;Shrestha S;Samie A;Mahfuz M;Qureshi S;Hotwani A;Babji S;Trigoso DR;Lima AA;Bodhidatta L;Bessong P;Ahmed T;Shakoor S;Kang G;Kosek M;Guerrant RL;Lang D;Gottlieb M;Houpt ER;Platts-Mills JA;Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project (MAL-ED) Network Investigators
通讯作者：
Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project (MAL-ED) Network Investigators
影响因子：
3.1
作者：
Baqar, Shahida;Applebee, Lisa A.;Guerry, Patricia
通讯作者：
Guerry, Patricia
影响因子：
8.8
作者：
Brunet, Yannick R.;Espinosa, Leon;Cascales, Eric
通讯作者：
Cascales, Eric