COVID-19 outcomes of 10,881 patients: retrospective study of neurological symptoms and associated manifestations (Philippine CORONA Study).
COVID-19 outcomes of 10,881 patients: retrospective study of neurological symptoms and associated manifestations (Philippine CORONA Study).
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DOI：
10.1007/s00702-021-02400-5
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Philippine CORONA Study Group Investigators
中科院分区：
文献类型：
--
作者：
Espiritu AI;Sy MCC;Anlacan VMM;Jamora RDG;Philippine CORONA Study Group Investigators
我们的研究旨在确定新发神经系统症状 (NNS) 对住院的 COVID-19 感染患者临床相关结果的影响。我们对菲律宾不同地区 37 个医院的住院 COVID-19 成人患者进行了一项全国范围的比较、回顾性队列研究。我们总共纳入了 10,881 名确诊的 COVID-19 感染患者（2008 年有 NNS，而 8873 名没有 NNS）。与非 NNS 组相比，NNS 组轻度和重症病例死亡率的调整后风险比 (aHR) 分别显着升高 1.660 (95% CI 1.132–2.435) 和 1.352 (95% CI 1.042–1.752)。 NNS组呼吸衰竭的aHR在轻度、重症和危重病例中分别显着增加1.914（95% CI 1.346-2.722）、1.614（95% CI 1.260-2.068）和1.234（95% CI 1.089-1.398）。 NNS 组入住 ICU 的 aHR 仍显着较高，轻度病例和重症病例分别高出 1.973 (95% CI 1.457–2.673) 和 1.831 (95% CI 1.506–2.226)。患有 NNS 的患者与较长的呼吸机依赖持续时间（调整后比值比 (aOR) 0.954，95% CI 0.772–1.179）、较长的 ICU 住院时间（aOR 0.983，95% CI 0.772–1.252）和较长的住院时间（aOR 1.045，95% CI）没有显着相关0.947–1.153）。 NNS 的存在显着增加了 COVID-19 患者的死亡、呼吸衰竭和入住 ICU 的风险。注册和相关方案发布：ClinicalTrials.gov 网站 (NCT04386083)； Espiritu AI、Sy MCC、Anlacan VMM、Jamora RDG。菲律宾 COVID-19 结果：神经表现和相关症状的回顾性研究（菲律宾 CORONA 研究）：一项方案研究。英国医学杂志公开赛。 2020；10：e040944。
Our study aimed to determine the effects of new-onset neurological symptoms (NNS) on clinically relevant outcomes in hospitalized patients with COVID-19 infection. We conducted a nationwide, comparative, retrospective, cohort study among adult, hospitalized COVID-19 patients involving 37 hospital sites from various regions in the Philippines. We included a total of 10,881 patients with confirmed COVID-19 infection (2008 had NNS while 8873 did not have NNS). The adjusted hazard ratios (aHRs) for mortality among the mild and severe cases were significantly higher by 1.660 (95% CI 1.132–2.435) and by 1.352 (95% CI 1.042–1.752), respectively, in the NNS group compared to those in the non-NNS group. The aHRs for respiratory failure in the NNS group were significantly increased by 1.914 (95% CI 1.346–2.722), by 1.614 (95% CI 1.260–2.068), and by 1.234 (95% CI 1.089–1.398) among the mild, severe, and critical cases, respectively. The aHRs for ICU admission in the NNS group were still significantly higher by 1.973 (95% CI 1.457–2.673) and by 1.831 (95% CI 1.506–2.226) among the mild and severe cases, respectively. Patients who had NNS were not significantly associated with a longer duration of ventilator dependence (adjusted odds ratio (aOR) 0.954, 95% CI 0.772–1.179), longer ICU stay (aOR 0.983, 95% CI 0.772–1.252) and longer hospital admission (aOR 1.045, 95% CI 0.947–1.153). The presence of NNS significantly increases the risk of mortality, respiratory failure and ICU admission among COVID-19 patients. Registration and associated protocol publication: ClinicalTrials.gov website (NCT04386083); Espiritu AI, Sy MCC, Anlacan VMM, Jamora RDG. The Philippine COVID-19 Outcomes: a Retrospective study Of Neurological manifestations and Associated symptoms (The Philippine CORONA study): a protocol study. BMJ Open. 2020;10:e040944.
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