Cerebrospinal fluid tau, Aβ, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration.
Cerebrospinal fluid tau, Aβ, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration.
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DOI：
10.1016/j.jalz.2018.05.004
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发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Stern RA
中科院分区：
文献类型：
--
作者：
Alosco ML;Tripodis Y;Fritts NG;Heslegrave A;Baugh CM;Conneely S;Mariani M;Martin BM;Frank S;Mez J;Stein TD;Cantu RC;McKee AC;Shaw LM;Trojanowski JQ;Blennow K;Zetterberg H;Stern RA
脑脊液 (CSF) 蛋白质分析可能有助于检测和阐明重复性头部撞击 (RHI) 造成的神经系统后果的机制，例如慢性创伤性脑病 (CTE)。我们检查了前国家橄榄球联盟 (NFL) 球员脑脊液中总 tau (t-tau)、磷酸化 tau (p-tau) 和 Aβ1-42 的浓度，以及它们与 RHI 的关联。小胶质细胞激活（使用 sTREM2）的作用被检查为 CTE 的致病机制。 68 名前 NFL 球员和 21 名对照者接受了腰椎穿刺，以使用免疫测定法定量脑脊液中的 t-tau、p-tau181、Aβ1-42 和 sTREM2。累积头部影响指数 (CHII) 估计 RHI。脑脊液分析物的组间差异没有出现。在前 NFL 球员中，CHII 预测较高的 t-tau 浓度 (p=0.041)，并且较高的 sTREM2 水平与较高的 t-tau 浓度相关 (p=0.009)。在这个前 NFL 球员样本中，较高的 RHI 和增加的小胶质细胞激活与较高的 CSF t-tau 浓度相关。
Cerebrospinal fluid (CSF) protein analysis may facilitate detection and elucidate mechanisms of neurological consequences from repetitive head impacts (RHI), such as chronic traumatic encephalopathy (CTE). We examined CSF concentrations of total tau (t-tau), phosphorylated tau (p-tau), and Aβ1–42, and their association with RHI in former National Football League (NFL) players. The role of microglial activation (using sTREM2) was examined as a pathogenic mechanism of CTE. Sixty-eight former NFL players and 21 controls underwent lumbar puncture to quantify t-tau, p-tau181, Aβ1–42, and sTREM2 in the CSF using immunoassays. The cumulative head impact index (CHII) estimated RHI. No between group differences for CSF analytes emerged. In the former NFL players, the CHII predicted higher t-tau concentrations (p=0.041) and higher sTREM2 levels were associated with higher t-tau concentrations (p=0.009). In this sample of former NFL players, greater RHI and increased microglial activation were associated with higher CSF t-tau concentrations.
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影响因子：
9.9
作者：
Hu, William T.;Watts, Kelly;Levey, Allan I.
通讯作者：
Levey, Allan I.
DOI：
10.1056/nejmoa1211851
发表时间：
2013-01-10
期刊：
The New England journal of medicine
影响因子：
--
作者：
Guerreiro R;Wojtas A;Bras J;Carrasquillo M;Rogaeva E;Majounie E;Cruchaga C;Sassi C;Kauwe JS;Younkin S;Hazrati L;Collinge J;Pocock J;Lashley T;Williams J;Lambert JC;Amouyel P;Goate A;Rademakers R;Morgan K;Powell J;St George-Hyslop P;Singleton A;Hardy J;Alzheimer Genetic Analysis Group
通讯作者：
Alzheimer Genetic Analysis Group
DOI：
10.1016/j.dadm.2016.11.003
发表时间：
2017
期刊：
Alzheimer's & dementia (Amsterdam, Netherlands)
影响因子：
--
作者：
Alosco ML;Tripodis Y;Jarnagin J;Baugh CM;Martin B;Chaisson CE;Estochen N;Song L;Cantu RC;Jeromin A;Stern RA
通讯作者：
Stern RA
影响因子：
5.3
作者：
Kitazawa, M;Oddo, S;LaFerla, FM
通讯作者：
LaFerla, FM
DOI：
10.1017/s1355617717000716
发表时间：
2018-01-01
影响因子：
2.6
作者：
Houck, Zac;Asken, Breton;Bauer, Russell
通讯作者：
Bauer, Russell