The fibromyalgia family study: a genome-wide linkage scan study.
The fibromyalgia family study: a genome-wide linkage scan study.
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DOI：
10.1002/art.37842
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发表时间：
2013-04
影响因子：
--
通讯作者：
Iyengar, Sudha K.
中科院分区：
文献类型：
--
作者：
Arnold, Lesley M.;Fan, Jinbo;Russell, I. Jon;Yunus, Muhammad B.;Khan, Muhammad Asim;Kushner, Irving;Olson, Jane M.;Iyengar, Sudha K.
纤维肌痛的家族聚集性已越来越多地认识到。本研究的目的是进行全基因组连锁扫描，以确定纤维肌痛的易感基因座。我们对来自纤维肌痛家族研究的116个家族的成员进行了基因分型，并使用Haseman-Elston回归方法对341个微卫星标记进行了无模型的纤维肌痛全基因组连锁分析。基于报告的人群患病率2%，估计的纤维肌痛同胞复发风险比（λs）为13.6（95% CI：10.0-18.5）。在染色体17p11.2-q11.2上的标记D17 S2196（经验P =0.00030）和D17 S1294（经验P =0.00035）处发现全基因组连锁的暗示证据。估计的同胞复发风险比表明纤维肌痛有很强的遗传成分。这是第一个报告纤维肌痛与染色体17p11.2-q11.2区域全基因组连锁的研究。对纤维肌痛家族研究中的这些多病例家族进行进一步调查，以确定纤维肌痛的潜在因果风险变体。
Familial aggregation of fibromyalgia has been increasingly recognized. The goal of the current study was to conduct a genome wide linkage scan to identify susceptibility loci for fibromyalgia. We genotyped members of 116 families from the Fibromyalgia Family Study and performed a model-free genome-wide linkage analysis of fibromyalgia with 341 microsatellite markers, using the Haseman-Elston regression approach. The estimated sibling recurrence risk ratio (λs) for fibromyalgia was 13.6 (95% CI: 10.0–18.5), based on a reported population prevalence of 2%. Genome-wide suggestive evidence of linkage was found at marker D17S2196 (Empirical P =0.00030) and D17S1294 (Empirical P =0.00035) on chromosome 17p11.2-q11.2. The estimated sibling recurrence risk ratio suggests a strong genetic component of fibromyalgia. This is the first study to report genome-wide suggestive linkage of fibromyalgia to the chromosome 17p11.2-q11.2 region. Further investigation of these multi-case families from the Fibromyalgia Family Study is warranted to identify potential causal risk variants for fibromyalgia.
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