Concise review: Dissecting a discrepancy in the literature: do mesenchymal stem cells support or suppress tumor growth?
Concise review: Dissecting a discrepancy in the literature: do mesenchymal stem cells support or suppress tumor growth?
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DOI：
10.1002/stem.559
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发表时间：
2011-01
期刊：
影响因子：
5.2
通讯作者：
Marini, Frank, III
中科院分区：
文献类型：
--
作者：
Klopp, Ann H.;Gupta, Anshul;Spaeth, Erika;Andreeff, Michael;Marini, Frank, III
在过去的十年中，在MSC的功能中，发现了间充质干细胞（MSC）的发现引起了很大的兴趣。为了确定其对肿瘤发育的影响，许多研究报告了结果与一些研究者相矛盾，一些研究人员发现MSC促进了肿瘤的生长，而其他研究人员则报告了MSC抑制肿瘤的生长。 MSC引入肿瘤可能是关键因素。治疗工具，并促进我们对肿瘤基质在癌变中的作用的理解
The discovery that mesenchymal stem cells (MSCs) are recruited into tumors has led to a great deal of interest over the past decade in the function of MSCs in tumors. To address this, investigators have used a variety of tumor models in which MSCs are added exogenously to determine their impact on tumor development. Interestingly, many studies have reported contradicting results, with some investigators finding that MSCs promote tumor growth and others reporting that MSCs inhibit tumor growth. Many mechanisms have been reported to account for these observations, such as chemokine signaling, modulation of apoptosis, vascular support, and immune modulation. In this review, we analyzed the differences in the methodology of the studies reported and found that the timing of MSC introduction into tumors may be a critical element. Understanding the conditions in which MSCs enhance tumor growth and metastasis is crucial, both to safely develop MSCs as a therapeutic tool and to advance our understanding of the role of tumor stroma in carcinogenesis. Stem Cells 2011;29:11–19
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血小板衍生的生长因子BB介导人间充质干细胞的性质因子神经胶质瘤。
影响因子：
4.8
作者：
Hata N;Shinojima N;Gumin J;Yong R;Marini F;Andreeff M;Lang FF
通讯作者：
Lang FF
影响因子：
3.7
作者：
Dasari VR;Kaur K;Velpula KK;Gujrati M;Fassett D;Klopfenstein JD;Dinh DH;Rao JS
通讯作者：
Rao JS
影响因子：
4.8
作者：
Kang SG;Shinojima N;Hossain A;Gumin J;Yong RL;Colman H;Marini F;Andreeff M;Lang FF
通讯作者：
Lang FF
DOI：
10.1111/j.1471-0528.2008.02005.x
发表时间：
2009-01-01
影响因子：
5.8
作者：
Gucciardo, L.;Lories, R.;Deprest, J.
通讯作者：
Deprest, J.
影响因子：
8
作者：
Galie, M.;Konstantinidou, G.;Amici, A.
通讯作者：
Amici, A.