Asymptomatic preclinical rheumatoid arthritis-associated interstitial lung disease.
Asymptomatic preclinical rheumatoid arthritis-associated interstitial lung disease.
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DOI：
10.1155/2013/406927
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发表时间：
2013
影响因子：
--
通讯作者：
Ascherman D
中科院分区：
文献类型：
--
作者：
Chen J;Shi Y;Wang X;Huang H;Ascherman D
目标。间质性肺病(ILD)是类风湿性关节炎(RA)常见的关节外表现，是导致发病率和死亡率的重要原因。这项研究的目的是明确高分辨率胸部CT(HRCT)和肺功能测试(PFT)异常能够识别无症状的、临床前形式的RA-ILD，这些可能代表更严重的纤维性肺疾病的先兆。方法：研究方法。我们分析了连续入选的RA患者的胸部HRCT，并根据是否存在磨玻璃样浑浊、间隔增厚、网状、牵引性支气管扩张和/或蜂窝征，将这些患者分为RA-ILD或RA-NO ILD。并存的PFT异常(预计FEV1、FVC、TLC和/或DLCO的百分比降低)也用于进一步确定隐匿性呼吸缺陷的特征。结果。根据HRCT和PFT异常，61%(63/103)的RA患者被归类为RA-ILD，39%(40/103)的患者被归类为RA-NO-ILD。在HRCT和PFT评估时，57/63名RA-ILD患者没有明显的呼吸困难或咳嗽症状。与RA-NON ILD相比，RA-ILD患者年龄大、病程长、关节病变活动度高、PFT异常明显。结论。HRCT是一种检测隐匿性/无症状ILD的有效工具，这种疾病在我们未经选择的大学RA患者队列中非常普遍。
Objective. Interstitial lung disease (ILD) is a common extra-articular manifestation of rheumatoid arthritis (RA) and a significant cause of morbidity and mortality. The objective of this study was to define high-resolution chest CT (HRCT) and pulmonary function test (PFT) abnormalities capable of identifying asymptomatic, preclinical forms of RA-ILD that may represent precursors to more severe fibrotic lung disease. Methods. We analyzed chest HRCTs in consecutively enrolled RA patients and subsequently classified these individuals as RA-ILD or RA-no ILD based on the presence/absence of ground glass opacification, septal thickening, reticulation, traction bronchiectasis, and/or honeycombing. Coexisting PFT abnormalities (reductions in percent predicted FEV1, FVC, TLC, and/or DLCO) were also used to further characterize occult respiratory defects. Results. 61% (63/103) of RA patients were classified as RA-ILD based on HRCT and PFT abnormalities, while 39% (40/103) were designated as RA-no ILD. 57/63 RA-ILD patients lacked symptoms of significant dyspnea or cough at the time of HRCT and PFT assessment. Compared with RA-no ILD, RA-ILD patients were older and had longer disease duration, higher articular disease activity, and more significant PFT abnormalities. Conclusion. HRCT represents an effective tool to detect occult/asymptomatic ILD that is highly prevalent in our unselected, university-based cohort of RA patients.
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类风湿性关节炎间质性肺疾病的发病率和死亡率：一项基于人群的研究。
影响因子：
--
作者：
Bongartz, Tim;Nannini, Carlotta;Medina-Velasquez, Yimy F.;Achenbach, Sara J.;Crowson, Cynthia S.;Ryu, Jay H.;Vassallo, Robert;Gabriel, Sherine E.;Matteson, Eric L.
通讯作者：
Matteson, Eric L.
影响因子：
9.6
作者：
Kim, Eunice J.;Collard, Harold R.;King, Talmadge E., Jr.
通讯作者：
King, Talmadge E., Jr.
影响因子：
5.5
作者：
Sawada, Tetsuji;Inokuma, Shigeko;Sagawa, Akira
通讯作者：
Sagawa, Akira
影响因子：
--
作者：
Gochuico, Bernadette R.;Avila, Nilo A.;Rosas, Ivan O.
通讯作者：
Rosas, Ivan O.
影响因子：
5
作者：
Ascherman, Dana P
通讯作者：
Ascherman, Dana P