Robocasting of multicomponent sol-gel–derived silicate bioactive glass scaffolds for bone tissue engineering
Robocasting of multicomponent sol-gel–derived silicate bioactive glass scaffolds for bone tissue engineering
复制标题
用于骨组织工程的多组分溶胶-凝胶衍生硅酸盐生物活性玻璃支架的机器人铸造
DOI：
10.1016/j.ceramint.2022.08.121
复制
发表时间：
2022
影响因子：
5.2
通讯作者：
F. Baino
中科院分区：
文献类型：
--
作者：
E. Fiume;J. Massera;D. d'Ambrosio;E. Verné;F. Baino
Robocasting被公认为是一种经济实惠且可重复的制造策略，用于以高度有序的多孔支架形式加工玻璃和玻璃陶瓷材料，用于骨组织工程（BTE）应用。然而，虽然被广泛应用于熔融衍生的生物活性玻璃，这种技术很少与溶胶-凝胶材料，由于在生产合适的油墨挤出，因此，良好的印刷结果的内在困难实施。本文介绍了一种制备多组分溶胶-凝胶生物活性硅酸盐支架的新方法（氧化物体系：47.5SiO2- 20 CaO-10 MgO-10 Na 2 O-10 K2 O-2.5P2O5，mol.%）使用干凝胶作为油墨组合物内的基本材料，这允许绕过通常对材料在生理环境中的生物活性潜力有害的中间热处理。的支架，表现出81体积%的总孔隙率，其特征在于在模拟体液（SBF）的形态组成特征和生物活性方面，特别注意浸泡后发生的离子释放和表面改性（磷灰石形成能力）。支架的抗压强度（约5 MPa）与人松质骨的抗压强度相当。总的来说，结果支持在BTE方法中使用robocast溶胶-凝胶衍生支架的可能性。此外，为了研究合成路线对最终生物材料的溶解行为和形态特征的影响，报告了与基于具有相同组成的熔融衍生玻璃的robocast支架的比较。
Robocasting is universally recognized as an affordable and reproducible manufacturing strategy to process glass and glass-ceramic materials in the form of highly ordered porous scaffolds for bone tissue engineering (BTE) applications. Nevertheless, while being widely applied to melt-derived bioactive glasses, this technique was seldom implemented with sol-gel materials due to the intrinsic difficulties in producing suitable inks for extrusion and thus, good printing outcomes. The present experimental work describes a new and relatively easy method to manufacture multicomponent sol-gel bioactive silicate scaffolds (oxide system: 47.5SiO2–20CaO–10MgO–10Na2O-10 K2O-2.5P2O5, mol.%) using dried gels as basic material within the ink composition, which allows by-passing intermediate heat treatments that are usually detrimental to the bioactive potential of the material in physiological environment. The scaffolds, exhibiting a total porosity of 81 vol%, were characterized in terms of morphological-compositional features and bioactivity in simulated body fluid (SBF), paying special attention to ion release and surface modifications occurring upon soaking (apatite-forming ability). The compressive strength of the scaffolds (around 5 MPa) was comparable to that of human cancellous bone. Collectively, the results supported the possibility of using robocast sol-gel–derived scaffolds in BTE approaches. Furthermore, a comparison with robocast scaffolds based on a melt-derived glass with the same composition was reported in order to investigate the effect of the synthesis route on the dissolution behavior and morphological features of the final biomaterials.
影响因子：
2.1
作者：
Blaess, Carsten;Mueller, Ralf;Brauer, Delia S.
通讯作者：
Brauer, Delia S.