An investigation of kV mini-GRID spatially fractionated radiation therapy: dosimetry and preclinical trial.
An investigation of kV mini-GRID spatially fractionated radiation therapy: dosimetry and preclinical trial.
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DOI：
10.1088/1361-6560/ac508c
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发表时间：
2022-02-18
影响因子：
3.5
通讯作者：
Oldham M
中科院分区：
文献类型：
--
作者：
Johnson TR;Bassil AM;Williams NT;Brundage S;Kent CL;Palmer G;Mowery YM;Oldham M
开发和表征极端空间分割千伏放射治疗的新方法(包括微型栅格治疗)，并在临床前小鼠研究的背景下评估疗效。空间分割栅格是从3毫米厚的铅板上精密铣削而成的，与安装在225KVP小型动物辐照器(X-Rad)上兼容。三个铅笔梁网格创建了直径为1 mm的梁阵列，三个条形网格创建了1×20 mm的矩形场。网格在等中心投影20×20mm2的场，梁间距分别为1、1.25和1.5 mm。用Gafchroic胶片评价峰谷比和剂量分布。C57BL/6小鼠腓肠肌肌肉注射软组织肉瘤细胞系诱发同种移植瘤。荷瘤小鼠被随机分为四组：未照射对照组、全瘤常规照射组、网格治疗组和半射野照射组(半射束阻断，肿瘤体积的50%处理)。所有受辐射的小鼠都接受了15Gy一次的照射。峰谷比较高(条形网格：11.9±0.9，13.6±0.4，13.8±0.5；笔形网格：18.7±0.6，26.3±1.5，31.0±3.3)。理论上，与条形网格相比，铅笔形网格可以节省更多的肿瘤内免疫细胞，但它们治疗的肿瘤组织更少(分别为3%-4%和19%-23%)。条形网格和半放射治疗显著延缓了肿瘤的生长(P<；0.001)，但不如传统治疗(P<；0.05)。在肿瘤生长延迟方面，网格照射组与半边照射组差异无统计学意义。千伏电网实现了很高的峰谷比：比文献中报道的中压电网的值高出两到五倍。网格照射和半照射均可延缓肿瘤生长，但均不如常规全瘤均一剂量治疗有效。单一分数网格治疗不能启动足够强的抗癌免疫反应，以匹配常规RT结果，但后续研究将评估微型网格与免疫检查点阻断的组合。
To develop and characterize novel methods of extreme spatially fractionated kV radiation therapy (including mini-GRID therapy) and to evaluate efficacy in the context of a pre-clinical mouse study. Spatially fractionated GRIDs were precision-milled from 3 mm thick lead sheets compatible with mounting on a 225 kVp small animal irradiator (X-Rad). Three pencil-beam GRIDs created arrays of 1 mm diameter beams, and three ‘bar’ GRIDs created 1 × 20 mm rectangular fields. GRIDs projected 20 × 20 mm2 fields at isocenter, and beamlets were spaced at 1, 1.25, and 1.5 mm, respectively. Peak-to-valley ratios and dose distributions were evaluated with Gafchromic film. Syngeneic transplant tumors were induced by intramuscular injection of a soft tissue sarcoma cell line into the gastrocnemius muscle of C57BL/6 mice. Tumor-bearing mice were randomized to four groups: unirradiated control, conventional irradiation of entire tumor, GRID therapy, and hemi-irradiation (half-beam block, 50% tumor volume treated). All irradiated mice received a single fraction of 15 Gy. High peak-to-valley ratios were achieved (bar GRIDs: 11.9 ± 0.9, 13.6 ± 0.4, 13.8 ± 0.5; pencil-beam GRIDs: 18.7 ± 0.6, 26.3 ± 1.5, 31.0 ± 3.3). Pencil-beam GRIDs could theoretically spare more intra-tumor immune cells than bar GRIDs, but they treat less tumor tissue (3%–4% versus 19%–23% area receiving 90% prescription, respectively). Bar GRID and hemi-irradiation treatments significantly delayed tumor growth (P < 0.05), but not as much as a conventional treatment (P < 0.001). No significant difference was found in tumor growth delay between GRID and hemi-irradiation. High peak-to-valley ratios were achieved with kV grids: two-to-five times higher than values reported in literature for MV grids. GRID irradiation and hemi-irradiation delayed tumor growth, but neither was as effective as conventional whole tumor uniform dose treatment. Single fraction GRID therapy could not initiate an anti-cancer immune response strong enough to match conventional RT outcomes, but follow-up studies will evaluate the combination of mini-GRID with immune checkpoint blockade.
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影响因子：
2.3
作者：
Duriseti S;Kavanaugh J;Goddu S;Price A;Knutson N;Reynoso F;Michalski J;Mutic S;Robinson C;Spraker MB
通讯作者：
Spraker MB
影响因子：
1.2
作者：
Amendola, Beatriz E.;Perez, Naipy C.;Qureshi, Ian Z.
通讯作者：
Qureshi, Ian Z.
影响因子：
3.5
作者：
Bazyar, Soha;Inscoe, Christina R.;Lee, Yueh Z.
通讯作者：
Lee, Yueh Z.
DOI：
10.1016/j.ijrobp.2018.10.009
发表时间：
2019-03-01
期刊：
International journal of radiation oncology, biology, physics
影响因子：
--
作者：
Markovsky E;Budhu S;Samstein RM;Li H;Russell J;Zhang Z;Drill E;Bodden C;Chen Q;Powell SN;Merghoub T;Wolchok JD;Humm J;Deasy JO;Haimovitz-Friedman A
通讯作者：
Haimovitz-Friedman A
DOI：
10.1016/j.ejmp.2015.04.014
发表时间：
2015-09-01
影响因子：
3.4
作者：
Bouchet, Audrey;Serduc, Raphaeel;Djonov, Valentin
通讯作者：
Djonov, Valentin