Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern.
Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern.
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两剂SARS-COV-2疫苗接种会引起对新兴SARS-COV-2的鲁棒反应。
DOI：
10.1038/s41467-021-25167-5
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发表时间：
2021-08-17
影响因子：
16.6
通讯作者：
James WS
中科院分区：
文献类型：
--
作者：
Skelly DT;Harding AC;Gilbert-Jaramillo J;Knight ML;Longet S;Brown A;Adele S;Adland E;Brown H;Medawar Laboratory Team;Tipton T;Stafford L;Mentzer AJ;Johnson SA;Amini A;OPTIC (Oxford Protective T cell Immunology for COVID-19) Clinical Group;Tan TK;Schimanski L;Huang KA;Rijal P;PITCH (Protective Immunity T cells in Health Care Worker) Study Group;C-MORE/PHOSP-C Group;Frater J;Goulder P;Conlon CP;Jeffery K;Dold C;Pollard AJ;Sigal A;de Oliveira T;Townsend AR;Klenerman P;Dunachie SJ;Barnes E;Carroll MW;James WS
对自然感染严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)的免疫反应和疫苗免疫在多大程度上保护人们关注的变种(VOC)具有越来越重要的意义。因此，我们在这里分析了最近接种疫苗的英国队列的抗体和T细胞，以及2020年初从自然感染中恢复的抗体和T细胞。我们表明，与原始循环谱系的参考分离物B相比，VOC的中和减少：对B.1.351的中和比对B.1.1.7的中和更深刻，在对感染或单剂疫苗的反应中比对第二剂疫苗的反应更明显。重要的是，在两次疫苗接种后会产生高强度的T细胞反应，其中大多数T细胞反应针对的是原型分离株B和VOC之间保守的表位。需要接种疫苗才能产生高效免疫反应，以预防这些和其他新出现的变种。了解疫苗接种对新出现的令人关注的SARS-CoV-2变种的影响越来越重要。在这里，詹姆斯等人。报告称，与自然感染相比，使用辉瑞-BioNTech疫苗的两剂疫苗对B.1.1.7和B.1.351 SARS-CoV-2谱系产生了更强大的免疫反应。
The extent to which immune responses to natural infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and immunization with vaccines protect against variants of concern (VOC) is of increasing importance. Accordingly, here we analyse antibodies and T cells of a recently vaccinated, UK cohort, alongside those recovering from natural infection in early 2020. We show that neutralization of the VOC compared to a reference isolate of the original circulating lineage, B, is reduced: more profoundly against B.1.351 than for B.1.1.7, and in responses to infection or a single dose of vaccine than to a second dose of vaccine. Importantly, high magnitude T cell responses are generated after two vaccine doses, with the majority of the T cell response directed against epitopes that are conserved between the prototype isolate B and the VOC. Vaccination is required to generate high potency immune responses to protect against these and other emergent variants. Understanding the effect of vaccination on emerging SARS-CoV-2 variants of concern is of increasing importance. Here, James et al. report that two doses of vaccination with the Pfizer-BioNTech vaccine induce more robust immune responses to the B.1.1.7 and B.1.351 SARS-CoV-2 lineages than does natural infection.
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离散的 SARS-CoV-2 抗体滴度与功能性体液稳定性保持一致。
影响因子：
16.6
作者：
Bartsch YC;Fischinger S;Siddiqui SM;Chen Z;Yu J;Gebre M;Atyeo C;Gorman MJ;Zhu AL;Kang J;Burke JS;Slein M;Gluck MJ;Beger S;Hu Y;Rhee J;Petersen E;Mormann B;Aubin MS;Hasdianda MA;Jambaulikar G;Boyer EW;Sabeti PC;Barouch DH;Julg BD;Musk ER;Menon AS;Lauffenburger DA;Nilles EJ;Alter G
通讯作者：
Alter G
影响因子：
64.5
作者：
Liu C;Ginn HM;Dejnirattisai W;Supasa P;Wang B;Tuekprakhon A;Nutalai R;Zhou D;Mentzer AJ;Zhao Y;Duyvesteyn HME;López-Camacho C;Slon-Campos J;Walter TS;Skelly D;Johnson SA;Ritter TG;Mason C;Costa Clemens SA;Gomes Naveca F;Nascimento V;Nascimento F;Fernandes da Costa C;Resende PC;Pauvolid-Correa A;Siqueira MM;Dold C;Temperton N;Dong T;Pollard AJ;Knight JC;Crook D;Lambe T;Clutterbuck E;Bibi S;Flaxman A;Bittaye M;Belij-Rammerstorfer S;Gilbert SC;Malik T;Carroll MW;Klenerman P;Barnes E;Dunachie SJ;Baillie V;Serafin N;Ditse Z;Da Silva K;Paterson NG;Williams MA;Hall DR;Madhi S;Nunes MC;Goulder P;Fry EE;Mongkolsapaya J;Ren J;Stuart DI;Screaton GR
通讯作者：
Screaton GR
影响因子：
28.3
作者：
Huang, Kuan-Ying A.;Rijal, Pramila;Townsend, Alain R.
通讯作者：
Townsend, Alain R.
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group
DOI：
10.1056/nejmoa2102214
发表时间：
2021-05-20
期刊：
The New England journal of medicine
影响因子：
--
作者：
Madhi SA;Baillie V;Cutland CL;Voysey M;Koen AL;Fairlie L;Padayachee SD;Dheda K;Barnabas SL;Bhorat QE;Briner C;Kwatra G;Ahmed K;Aley P;Bhikha S;Bhiman JN;Bhorat AE;du Plessis J;Esmail A;Groenewald M;Horne E;Hwa SH;Jose A;Lambe T;Laubscher M;Malahleha M;Masenya M;Masilela M;McKenzie S;Molapo K;Moultrie A;Oelofse S;Patel F;Pillay S;Rhead S;Rodel H;Rossouw L;Taoushanis C;Tegally H;Thombrayil A;van Eck S;Wibmer CK;Durham NM;Kelly EJ;Villafana TL;Gilbert S;Pollard AJ;de Oliveira T;Moore PL;Sigal A;Izu A;NGS-SA Group;Wits-VIDA COVID Group
通讯作者：
Wits-VIDA COVID Group