Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum.
Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum.
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DOI：
10.1016/j.cell.2021.06.020
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发表时间：
2021-08-05
期刊：
影响因子：
64.5
通讯作者：
Screaton GR
中科院分区：
文献类型：
--
作者：
Liu C;Ginn HM;Dejnirattisai W;Supasa P;Wang B;Tuekprakhon A;Nutalai R;Zhou D;Mentzer AJ;Zhao Y;Duyvesteyn HME;López-Camacho C;Slon-Campos J;Walter TS;Skelly D;Johnson SA;Ritter TG;Mason C;Costa Clemens SA;Gomes Naveca F;Nascimento V;Nascimento F;Fernandes da Costa C;Resende PC;Pauvolid-Correa A;Siqueira MM;Dold C;Temperton N;Dong T;Pollard AJ;Knight JC;Crook D;Lambe T;Clutterbuck E;Bibi S;Flaxman A;Bittaye M;Belij-Rammerstorfer S;Gilbert SC;Malik T;Carroll MW;Klenerman P;Barnes E;Dunachie SJ;Baillie V;Serafin N;Ditse Z;Da Silva K;Paterson NG;Williams MA;Hall DR;Madhi S;Nunes MC;Goulder P;Fry EE;Mongkolsapaya J;Ren J;Stuart DI;Screaton GR
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）经历了渐进性变化，具有优势的变异体迅速成为优势谱系，例如，B.1.617.变异B.1.617.2的传染性明显增加，助长了目前肆虐印度次大陆的感染浪潮，在联合王国被指定为令人关切的变异。在这里，我们研究的能力，单克隆抗体和恢复期和疫苗血清中和B.1.617.1和B.1.617.2，补充这与Fab/受体结合域（RBD）复合物的结构分析，并映射当前变体的抗原空间。与祖先武汉相关毒株相比，两种病毒的中和作用均降低，但没有证据表明B.1.351存在广泛的抗体逃逸。然而，B.1.351和P.1血清显示B.1.617.2的中和作用明显降低，表明先前感染这些变体的个体可能更容易再次感染B.1.617.2。这一观察结果为未来在非免疫人群中使用变异疫苗的免疫政策提供了重要的新见解。疫苗/恢复期血清显示B.1.617.1和B.1.617.2的中和作用降低来自B.1.351和P.1的血清显示B.1.617.2的中和作用显著降低B.1.351、P.1和B.1.617.2在抗原性上是不同的基于B.1.1.7的疫苗可以广泛地保护抵抗当前的变体SARS-CoV-2的B.1.617谱系，特别是德尔塔病毒株，即B.1.617.2，导致了印度次大陆的感染浪潮。结构和血清学分析显示了抗体逃逸的一些证据，先前感染B.1.351（β）和P.1（γ）变体的个体可能更容易被δ菌株再次感染。基于B.1.1.7（alpha）的疫苗可能提供针对当前变体的最广泛保护。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has undergone progressive change, with variants conferring advantage rapidly becoming dominant lineages, e.g., B.1.617. With apparent increased transmissibility, variant B.1.617.2 has contributed to the current wave of infection ravaging the Indian subcontinent and has been designated a variant of concern in the United Kingdom. Here we study the ability of monoclonal antibodies and convalescent and vaccine sera to neutralize B.1.617.1 and B.1.617.2, complement this with structural analyses of Fab/receptor binding domain (RBD) complexes, and map the antigenic space of current variants. Neutralization of both viruses is reduced compared with ancestral Wuhan-related strains, but there is no evidence of widespread antibody escape as seen with B.1.351. However, B.1.351 and P.1 sera showed markedly more reduction in neutralization of B.1.617.2, suggesting that individuals infected previously by these variants may be more susceptible to reinfection by B.1.617.2. This observation provides important new insights for immunization policy with future variant vaccines in non-immune populations. Vaccine/convalescent sera show reduced neutralization of B.1.617.1 and B.1.617.2 Sera from B.1.351and P.1 show markedly reduced neutralization of B.1.617.2 B.1.351, P.1, and B.1.617.2 are antigenically divergent Vaccines based on B.1.1.7 may protect broadly against current variants The B.1.617 lineage of SARS-CoV-2, especially the delta strain, which is B.1.617.2, has contributed to the wave of infection in the Indian subcontinent. Structural and serological analyses show some evidence of antibody escape, and individuals infected previously with the B.1.351 (beta) and P.1 (gamma) variants are likely more susceptible to reinfection by the delta strain. Vaccines based on B.1.1.7 (alpha) are likely to provide the broadest protection against current variants.
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SARS-COV-2血统的估计可传播和影响B.1.1.7在英国。
DOI：
10.1126/science.abg3055
发表时间：
2021-04-09
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Davies NG;Abbott S;Barnard RC;Jarvis CI;Kucharski AJ;Munday JD;Pearson CAB;Russell TW;Tully DC;Washburne AD;Wenseleers T;Gimma A;Waites W;Wong KLM;van Zandvoort K;Silverman JD;CMMID COVID-19 Working Group;COVID-19 Genomics UK (COG-UK) Consortium;Diaz-Ordaz K;Keogh R;Eggo RM;Funk S;Jit M;Atkins KE;Edmunds WJ
通讯作者：
Edmunds WJ
影响因子：
64.5
作者：
Dejnirattisai W;Zhou D;Ginn HM;Duyvesteyn HME;Supasa P;Case JB;Zhao Y;Walter TS;Mentzer AJ;Liu C;Wang B;Paesen GC;Slon-Campos J;López-Camacho C;Kafai NM;Bailey AL;Chen RE;Ying B;Thompson C;Bolton J;Fyfe A;Gupta S;Tan TK;Gilbert-Jaramillo J;James W;Knight M;Carroll MW;Skelly D;Dold C;Peng Y;Levin R;Dong T;Pollard AJ;Knight JC;Klenerman P;Temperton N;Hall DR;Williams MA;Paterson NG;Bertram FKR;Siebert CA;Clare DK;Howe A;Radecke J;Song Y;Townsend AR;Huang KA;Fry EE;Mongkolsapaya J;Diamond MS;Ren J;Stuart DI;Screaton GR
通讯作者：
Screaton GR
影响因子：
28.3
作者：
Gorbalenya, Alexander E.;Baker, Susan C.;Ziebuhr, John
通讯作者：
Ziebuhr, John
DOI：
10.1107/s0907444904019158
发表时间：
2004-12-01
影响因子：
2.2
作者：
Emsley, P;Cowtan, K
通讯作者：
Cowtan, K
影响因子：
64.5
作者：
Garcia-Beltran, Wilfredo F.;Lam, Evan C.;Balazs, Alejandro B.
通讯作者：
Balazs, Alejandro B.