Mitochondrial DNA copy number is associated with risk of head and neck squamous cell carcinoma in Chinese population.
Mitochondrial DNA copy number is associated with risk of head and neck squamous cell carcinoma in Chinese population.
复制标题
线粒体DNA拷贝数与中国人群头颈鳞状细胞癌的风险相关
作者：
Wang L;Lv H;Ji P;Zhu X;Yuan H;Jin G;Dai J;Hu Z;Su Y;Ma H
线粒体在细胞生物能量和许多重要的生理活动中发挥着特殊作用。先前的研究表明，线粒体 DNA 拷贝数的变化有助于不同类型癌症的发生。然而，外周血白细胞（PBL）中线粒体DNA拷贝数与头颈鳞状细胞癌（HNSCC）风险的关系仍无定论。我们通过一项病例对照研究调查了 mtDNA 与 HNSCC 风险的关联，该研究包括 570 例 HNSCC 病例和 597 例无癌症对照。通过实时 qPCR 测量 PBL 中的线粒体 DNA 拷贝数。进行逻辑回归来估计 PBL 中 mtDNA 拷贝数与 HNSCC 风险之间的关联。研究发现 mtDNA 拷贝数与 HNSCC 风险之间存在 U 形关系。与第二个四分位数组相比，第一和第四四分位数组的调整后优势比（OR）和95%置信区间（CI）分别为1.95（1.37-2.76）和2.16（1.53-3.04）。通过限制三次样条分析，我们证实了这种显着的 U 形关系。此外，在按年龄、性别、吸烟和饮酒分层的不同亚组中，U 形关联仍然显着。极低和极高的线粒体 DNA 拷贝数均与 HNSCC 风险增加显着相关。
Mitochondria show the special role in cellular bioenergy and many essential physiological activities. Previous researches have suggested that variations of mitochondrial DNA copy number contribute to development of different types of carcinomas. However, the relationship of mtDNA copy number in peripheral blood leukocytes (PBLs) with the risk of head and neck squamous cell carcinoma (HNSCC) is still inconclusive. We investigated the association of mtDNA with HNSCC risk through a case–control study including 570 HNSCC cases and 597 cancer‐free controls. mtDNA copy number in PBLs was measured by real‐time qPCR. Logistic regression was performed to estimate the association between the mtDNA copy number in PBLs and HNSCC risk. A U‐shaped relation between the mtDNA copy number and HNSCC risk was found. Compared with those in the second quartile group, the adjusted odds ratios (ORs) and 95% confidence interval (CI) for those in the first and the forth quartile groups were 1.95 (1.37–2.76) and 2.16 (1.53–3.04), respectively. Using restricted cubic spline analysis, we confirmed such a significant U‐shaped relation. Furthermore, the U‐shaped association remained significant in different subgroups stratified by age, gender, tobacco smoking, and alcohol consumption. Both extremely low and high mtDNA copy numbers had significant associations with the increased HNSCC risk.
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影响因子：
7.7
作者：
Ju YS;Alexandrov LB;Gerstung M;Martincorena I;Nik-Zainal S;Ramakrishna M;Davies HR;Papaemmanuil E;Gundem G;Shlien A;Bolli N;Behjati S;Tarpey PS;Nangalia J;Massie CE;Butler AP;Teague JW;Vassiliou GS;Green AR;Du MQ;Unnikrishnan A;Pimanda JE;Teh BT;Munshi N;Greaves M;Vyas P;El-Naggar AK;Santarius T;Collins VP;Grundy R;Taylor JA;Hayes DN;Malkin D;ICGC Breast Cancer Group;ICGC Chronic Myeloid Disorders Group;ICGC Prostate Cancer Group;Foster CS;Warren AY;Whitaker HC;Brewer D;Eeles R;Cooper C;Neal D;Visakorpi T;Isaacs WB;Bova GS;Flanagan AM;Futreal PA;Lynch AG;Chinnery PF;McDermott U;Stratton MR;Campbell PJ
通讯作者：
Campbell PJ
DOI：
10.1158/1940-6207.capr-10-0326
发表时间：
2011-05
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Chatterjee A;Dasgupta S;Sidransky D
通讯作者：
Sidransky D
影响因子：
4.7
作者：
Hosgood, H. Dean, III;Liu, Chin-San;Lan, Qing
通讯作者：
Lan, Qing
影响因子：
3.5
作者：
Liu, CS;Cheng, WL;Wei, YH
通讯作者：
Wei, YH
影响因子：
4.7
作者：
He, Yonggang;Gong, Yilei;Wu, Xifeng
通讯作者：
Wu, Xifeng