Bioenergetic Metabolism In Osteoblast Differentiation.
Bioenergetic Metabolism In Osteoblast Differentiation.
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DOI：
10.1007/s11914-022-00721-2
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发表时间：
2022-03
影响因子：
4.3
通讯作者：
中科院分区：
文献类型：
--
作者：
成骨细胞负责骨骼发育和稳态过程中骨基质的产生。关于控制成骨细胞分化的转录调控和信号传导途径已经有很多了解。然而，人们对成骨细胞如何获取或利用营养物质来满足与成骨细胞分化和骨基质合成相关的能量需求知之甚少。本综述的目的是强调和讨论关于成骨细胞生物能代谢的作用和调节的已知信息，重点关注最近的研究。生物能代谢已成为成骨细胞的重要调节节点。最近的研究已经开始确定成骨细胞喜欢的主要营养物质和生物能途径及其在分化过程中的调节。在这里，我们重点介绍成骨细胞如何获取和代谢葡萄糖、氨基酸和脂肪酸以提供能量和其他代谢中间体。此外，我们强调调节营养吸收和代谢的信号，并关注能量代谢如何促进成骨细胞分化。生物能代谢提供对成骨细胞分化和活性至关重要的能量和其他代谢物。这些知识有助于更全面地了解成骨细胞生物学，并可能为调节骨疾病患者的成骨细胞分化和骨合成代谢提供新策略。
Osteoblasts are responsible for bone matrix production during bone development and homeostasis. Much is known about the transcriptional regulation and signaling pathways governing osteoblast differentiation. However, less is known about how osteoblasts obtain or utilize nutrients to fulfill the energetic demands associated with osteoblast differentiation and bone matrix synthesis. The goal of this review is to highlight and discuss what is known about the role and regulation of bioenergetic metabolism in osteoblasts with a focus on more recent studies. Bioenergetic metabolism has emerged as an important regulatory node in osteoblasts. Recent studies have begun to identify the major nutrients and bioenergetic pathways favored by osteoblasts as well as their regulation during differentiation. Here, we highlight how osteoblasts obtain and metabolize glucose, amino acids and fatty acids to provide energy and other metabolic intermediates. In addition, we highlight the signals that regulate nutrient uptake and metabolism and focus on how energetic metabolism promotes osteoblast differentiation. Bioenergetic metabolism provides energy and other metabolites that are critical for osteoblast differentiation and activity. This knowledge contributes to a more comprehensive understanding of osteoblast biology and may inform novel strategies to modulate osteoblast differentiation and bone anabolism in patients with bone disorders.
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影响因子：
29
作者：
Ambrogini E;Almeida M;Martin-Millan M;Paik JH;Depinho RA;Han L;Goellner J;Weinstein RS;Jilka RL;O'Brien CA;Manolagas SC
通讯作者：
Manolagas SC
影响因子：
4.1
作者：
ADAMEK, G;FELIX, R;FLEISCH, H
通讯作者：
FLEISCH, H
影响因子：
11.2
作者：
D'Aniello, Cristina;Cermola, Federica;Minchiotti, Gabriella
通讯作者：
Minchiotti, Gabriella
影响因子：
4.6
作者：
Dobson, Philip F.;Dennis, Ella P.;Greaves, Laura C.
通讯作者：
Greaves, Laura C.
影响因子：
5.7
作者：
Gross, Matt I.;Demo, Susan D.;Bennett, Mark K.
通讯作者：
Bennett, Mark K.