DNA vaccine strategies for the treatment of cancer.-猫眼课题宝

治疗癌症的 DNA 疫苗策略。

DOI：

发表时间：

1998

期刊：

Current Topics in Microbiology and Immunology

影响因子：

通讯作者：

中科院分区：

医学3区

文献类型：

作者：

P. Benton;R. Kennedy

目前正在动物模型和临床人体试验中研究用于治疗癌症的多种免疫策略（Dranoff和Mulligan 1995中综述）。这些包括在存在或不存在重组细胞因子的情况下肿瘤特异性细胞毒性T细胞的体外扩增和过继转移（Rosenberg等1985，1986，1988，1989，1991，1993; Teng等1991），基于肿瘤抗原的疫苗（Cheever et al.1986; Bright et al.1994 a; Conry et al.1994;史蒂文森et al.1995），和与毒素缀合的肿瘤反应性单克隆抗体（Trail et al.1993; Vivetta et al.1993）。最新的创新战略之一是基于遗传免疫的概念。现在已经确定，用编码特定基因的质粒DNA接种疫苗可以引发对各种感染因子的强的、长期的保护性免疫应答（综述于Ulmer et al. 1996; Whalen 1996）以及某些肿瘤（Conry等，1994; Nabel等，1994 b;史蒂文森等，1995; Bright等，1996; Corr等，1996; Schirmbeck等，1996）。针对引发针对肿瘤的免疫应答的DNA疫苗似乎为癌症的预防性和治疗性治疗提供了希望。

A wide variety of immunotherapeutic strategies for the treatment of cancers is currently under investigation in both animal models and in clinical human trials (reviewed in Dranoff and Mulligan 1995). These include in vitro expansion and adoptive transfer of tumor-specific cytotoxic T cells in the presence or absence of recombinant cytokines (Rosenberg et al. 1985, 1986, 1988, 1989, 1991, 1993; Teng et al. 1991), tumor antigen-based vaccines (Cheever et al. 1986; Bright et al. 1994a; Conry et al. 1994; Stevenson et al. 1995), and tumor-reactive monoclonal antibodies conjugated to toxins (Trail et al. 1993; Vivetta et al. 1993). One of the most recent and innovative strategies has been based on the concept of genetic immunization. It is now well established that vaccination with plasmid DNA encoding a specific gene can elicit strong, long-lived protective immune responses to a variety of infectious agents (reviewed in Ulmer et al. 1996; Whalen 1996) as well as certain tumors (Conry et al. 1994; Nabel et al. 1994b; Stevenson et al. 1995; Bright et al. 1996; Corr et al. 1996; Schirmbeck et al. 1996). DNA vaccines directed at eliciting an immune response toward tumors appear to offer promise for both the prophylactic and therapeutic treatment of cancer.