Abnormal structural and functional brain connectivity in gray matter heterotopia.
Abnormal structural and functional brain connectivity in gray matter heterotopia.
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DOI：
10.1111/j.1528-1167.2012.03466.x
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发表时间：
2012-06
期刊：
影响因子：
5.6
通讯作者：
Chang BS
中科院分区：
文献类型：
--
作者：
Christodoulou JA;Walker LM;Del Tufo SN;Katzir T;Gabrieli JD;Whitfield-Gabrieli S;Chang BS
脑室周围结节异位症(PNH)是一种与癫痫和阅读障碍相关的皮质发育畸形。有证据表明，异位灰质在脑畸形中可以发挥功能，连接异常在这些疾病中可能是重要的。我们假设结节异位发展异常连接，并系统地研究了PNH患者异位的结构和功能连接。11名受试者接受了扩散张量纤维束成像和静息状态功能连接性MRI的BOLD氧合水平依赖(BOLD)成像研究。异位结节内有末端的纤维轨迹被可视化以确定结构连通性，并分析了显示静息状态功能与异位结节相关的脑区。这些连接结果与临床癫痫和认知障碍的测量之间的关系被检查。大多数异位症(69%)显示出与上皮层离散区域的结构连接，几乎所有(96%)显示出与这些区域的功能连接(平均峰值相关系数0.61)。异位症还表现出与对侧皮质、其他异位结节、同侧但不覆盖的皮质以及深部灰质结构或小脑的连接。癫痫持续时间越长的受试者，功能连接异常程度越高(p=0.036)。大多数PNH的异位结节在结构和功能上都与上皮层相连，且癫痫持续时间最长的异位结节连接异常的强度较高。除了先前的证据表明，皮质皮质束缺陷是这种疾病的阅读障碍的基础，目前的发现表明，连接改变可能是脑畸形患者神经功能障碍的关键底物。
Periventricular nodular heterotopia (PNH) is a malformation of cortical development associated with epilepsy and dyslexia. Evidence suggests that heterotopic gray matter can be functional in brain malformations and that connectivity abnormalities may be important in these disorders. We hypothesized that nodular heterotopia develop abnormal connections and systematically investigated the structural and functional connectivity of heterotopia in patients with PNH. Eleven subjects were studied using diffusion tensor tractography and resting-state functional connectivity MRI with bold oxygenation level-dependent (BOLD) imaging. Fiber tracks with a terminus within heterotopic nodules were visualized to determine structural connectivity, and brain regions demonstrating resting-state functional correlations to heterotopic nodules were analyzed. Relationships between these connectivity results and measures of clinical epilepsy and cognitive disability were examined. A majority of heterotopia (69%) showed structural connectivity to discrete regions of overlying cortex, and almost all (96%) showed functional connectivity to these regions (mean peak correlation coefficient 0.61). Heterotopia also demonstrated connectivity to regions of contralateral cortex, other heterotopic nodules, ipsilateral but nonoverlying cortex, and deep gray matter structures or the cerebellum. Subjects with the longest durations of epilepsy had a higher degree of abnormal functional connectivity (p=0.036). Most heterotopic nodules in PNH are structurally and functionally connected to overlying cortex, and the strength of abnormal connectivity is higher among those with the longest durations of epilepsy. Along with prior evidence that cortico-cortical tract defects underlie dyslexia in this disorder, the current findings suggest that altered connectivity is likely a critical substrate for neurological dysfunction in brain malformations.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5.6
作者：
Meroni, Alessandra;Galli, Carlo;Spreafico, Roberto
通讯作者：
Spreafico, Roberto
影响因子：
14.5
作者：
Hannan, AJ;Servotte, S;Molnár, Z
通讯作者：
Molnár, Z
影响因子：
14.5
作者：
Eriksson, SH;Rugg-Gunn, EJ;Duncan, JS
通讯作者：
Duncan, JS
影响因子：
16.2
作者：
Fox, JW;Lamperti, ED;Walsh, CA
通讯作者：
Walsh, CA