Evaluation of vessel density in disorganization of retinal inner layers after resolved diabetic macular edema using optical coherence tomography angiography.
Evaluation of vessel density in disorganization of retinal inner layers after resolved diabetic macular edema using optical coherence tomography angiography.
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DOI：
10.1371/journal.pone.0244789
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Tranfa F
中科院分区：
文献类型：
--
作者：
Cennamo G;Montorio D;Fossataro F;Fossataro C;Tranfa F
应用光学相干断层血管造影（OCTA）评价糖尿病性黄斑水肿消退后视网膜内层紊乱（DRILs）和非视网膜内层紊乱（DRILs）患者黄斑区视网膜血管密度（VD）和中央凹无血管区（FAZ）区域。37例DRIL患者37眼（平均年龄63±13.97岁），30例非DRIL患者30眼，35例对照35眼。观察黄斑区浅毛细血管丛（SCP）、深毛细血管丛（DCP）和FAZ区的VD。与对照组相比，注射和未注射组SCP和DCP的VD降低（p<0.05）， FAZ面积增大（p<0.001）。然而，与没有DRIL的患者相比，DRIL患者的SCP VD有统计学意义的降低（p = 0.041）， FAZ面积更大（p<0.001）。我们发现DRIL组中央凹SCP VD （r = -0.414, p = 0.011）、中央凹DCP （r = -0.358, p = 0.025）与最佳矫正视力（BCVA）呈显著负相关。FAZ面积与BCVA呈显著正相关（r = 0.425, p = 0.034）。因此，有DRILs存在时，较低的SCP和DCP VD值和较大的FAZ面积与较差的视力相关。在无DRILs组，中央凹DCP VD与BCVA呈显著负相关。OCTA强调视网膜血管缺血在DRILs发病机制中的作用。该参数可能是糖尿病患者一个重要的功能预测因素。
To evaluate the retinal vessel density (VD) in the macular region and the foveal avascular zone (FAZ) area using optical coherence tomography angiography (OCTA) in patients with and without disorganization of retinal inner layers (DRILs) after resolution of diabetic macular edema. Thirty-seven eyes of 37 DRIL patients (mean age 63 ± 13.97 years), 30 eyes of 30 no DRIL patients and 35 eyes of 35 controls were enrolled in this study. We evaluated the VD in the macular region of superficial capillary plexus (SCP), deep capillary plexus (DCP) and FAZ area. DRIL and no DRIL groups showed decreased VD in SCP and DCP (p<0.05) and a larger FAZ area (p<0.001) compared to controls. However, DRIL patients revealed a statistically significant reduction in VD of SCP (p = 0.041) and a greater FAZ area (p<0.001) with respect to no DRIL patients. We found a significant negative correlation between the VD of the foveal SCP (r = -0.414, p = 0.011), foveal DCP (r = -0.358, p = 0.025) and best corrected visual acuity (BCVA) in DRIL group. Moreover there was a significant positive correlation between the FAZ area (r = 0.425, p = 0.034) and BCVA. Therefore, in presence of DRILs lower VD values of SCP and DCP and a larger FAZ area correlated with a worse visual acuity. In no DRILs group, there was a significant negative correlation between the VD of the foveal DCP and BCVA. OCTA highlights the role of retinal vascular ischemia in the pathogenesis of DRILs. This parameter could represent an important functional predictive factor in diabetic patients.
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影响因子：
3.8
作者：
Jia Y;Tan O;Tokayer J;Potsaid B;Wang Y;Liu JJ;Kraus MF;Subhash H;Fujimoto JG;Hornegger J;Huang D
通讯作者：
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作者：
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