Clinical and epidemiological characterization of influenza virus infections in children with severe acute respiratory infection in Maputo, Mozambique: Results from the implementation of sentinel surveillance, 2014 - 2016.
Clinical and epidemiological characterization of influenza virus infections in children with severe acute respiratory infection in Maputo, Mozambique: Results from the implementation of sentinel surveillance, 2014 - 2016.
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DOI：
10.1371/journal.pone.0194138
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Mussá T
中科院分区：
文献类型：
--
作者：
Nguenha N;Tivane A;Pale M;Machalele L;Nacoto A;Pires G;Mationane E;Salência J;Gundane F;Muteto D;Chilundo J;Mavale S;Adamo N;Semá-Baltazar C;Augusto O;Gudo E;Mussá T
在撒哈拉以南非洲，急性呼吸道感染（ARI）的负担、影响和发病率是世界上最高的，相反，与流感相关的严重急性呼吸道感染（SARI）的流行病学尚不完全清楚。本研究的目的是描述莫桑比克马普托市住院儿童流感相关急性呼吸道感染的临床和流行病学特征。在马普托市两家医院采集符合急性呼吸道感染病例定义的0-14岁儿童的鼻咽和口咽拭子，经其父母或法定代理人同意参与。采用结构化问卷收集临床和人口统计数据。实时荧光定量PCR检测流感病毒分型和亚型。2014年1月至2016年12月，共招募了2007名符合条件的儿童，其中1997名（99.5%）通过实时PCR筛查流感。参与者的中位年龄为16.9个月（IQR: 7.0-38.9个月），53.9%（1076/1991）为男性。共有77人流感呈阳性反应，发病率为3.9%(77/ 1991)，据报告发病率最高的是1-5岁年龄组。流感病例每年达到两次高峰，发病频率高达60%-80%。在所有流感确诊病例中，A/H3N2型占33.7% (26/77)，A/H1N1pdm09型占35.1% (27/77)，B型占28.6%（22/77）。这是莫桑比克城市/城郊环境中首次报告流感病例，也是该国流感毒株分布的首次证据。我们的数据显示，流感的频率低于莫桑比克农村地区的报告，季节性（a /H1N1pdm09）和（a /H3N2）亚型在严重急性呼吸道感染儿童中的频率相似。
In Sub-Saharan Africa, where burden, impact, and incidence of acute respiratory infections (ARI) are the highest in the world, conversely, the epidemiology of influenza-associated severe acute respiratory infections (SARI) is incompletely known. The aim of this study was to describe the clinical and epidemiological features of influenza-associated SARI in hospitalized children in Maputo city, Mozambique. Nasopharyngeal and oropharyngeal swabs were collected from children aged 0–14 years old who met the case definition for SARI in two hospitals in Maputo city after their parents or legal representative consented to participate. A structured questionnaire was used to collect clinical and demographic data. Typing and subtyping of influenza were performed by real-time PCR. From January 2014 to December 2016, a total of 2,007 eligible children were recruited, of whom 1,997 (99.5%) were screened for influenza by real-time PCR. The median age of participants was 16.9 months (IQR: 7.0–38.9 months) and 53.9% (1076/1991) were male. A total of 77 were positive for influenza, yielding a frequency of 3.9% (77/1,991), with the highest frequency being reported in the age group 1–5 years old. Cases of influenza peaked twice each year, during which, its frequency reached up to 60%-80%. Among all influenza confirmed cases, 33.7% (26/77), 35.1% (27/77) and 28.6% (22/77) were typed as influenza A/H3N2, A/H1N1pdm09, and B, respectively. This represents the first report of influenza in urban/sub urban setting in Mozambique and the first evidence of distribution of strains of influenza in the country. Our data showed that frequency of influenza was lower than reported in a rural setting in Mozambique and the frequency of seasonal (A/H1N1pdm09) and (A/H3N2) subtypes were similar in children with SARI.
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影响因子：
8.8
作者：
Pretorius, Marthi A.;Tempia, Stefano;Venter, Marietjie
通讯作者：
Venter, Marietjie
DOI：
10.1016/j.jmii.2015.05.015
发表时间：
2016-06-01
影响因子：
7.4
作者：
Ma, Hsuan-Yin;Wu, Jhong-Lin;Huang, Li-Min
通讯作者：
Huang, Li-Min
影响因子：
6.4
作者：
Heraud, Jean-Michel;Njouom, Richard;Diop, Ousmane Madiagne
通讯作者：
Diop, Ousmane Madiagne
影响因子：
3.7
作者：
Maïnassara HB;Lagare A;Tempia S;Sidiki A;Issaka B;Abdou Sidikou B;Oukem-Boyer OO
通讯作者：
Oukem-Boyer OO
影响因子：
4.4
作者：
Alonso WJ;Guillebaud J;Viboud C;Razanajatovo NH;Orelle A;Zhou SZ;Randrianasolo L;Heraud JM
通讯作者：
Heraud JM