Macular Vascular Geometry Changes With Sex and Age in Healthy Subjects: A Fundus Photography Study.
Macular Vascular Geometry Changes With Sex and Age in Healthy Subjects: A Fundus Photography Study.
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DOI：
10.3389/fmed.2021.778346
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发表时间：
2021
影响因子：
3.9
通讯作者：
Yuan J
中科院分区：
文献类型：
--
作者：
Feng Z;Wang G;Xia H;Li M;Liang G;Dong T;Xiao P;Yuan J
目的：利用眼底照相术描述健康人群中黄斑血管几何形状的性别和年龄相关改变。研究方法：对305例（男136例，女169例）健康体检者的610只眼进行了眼底照相检查，并将其分为4个年龄组（G1 ≤ 25岁，G2 26-35岁，G3 36-45岁，G4 ≥ 46岁）。根据早期治疗糖尿病视网膜病变研究（ETDRS），自行开发的自动化视网膜血管分析系统允许对黄斑血管网络进行分割和单独的多参数定量。计算血管分形维数（Df）、血管面积率（VAR）、血管平均直径（Dm）、血管迂曲度（τn），并进行性别和年龄组间比较。结果如下：男女受试者的平均年龄（分别为32.706 ± 10.372和33.494 ± 10.620，p > 0.05）和各年龄组男女的平均年龄之间无显著性差异（p > 0.05）。男性内环的Df、VAR和Dm、外环的Df以及整个黄斑的Df和VAR均明显大于女性（分别为p < 0.001、p < 0.001、p < 0.05）。τn在男女之间无显著性差异（p > 0.05）。全黄斑、内外环的Df、VAR和Dm与年龄呈负相关（p < 0.001），而τn与年龄无显著相关（p > 0.05）。年龄组间比较，内环Df从G2开始较G1降低（p < 0.05），全黄斑、内环和外环Df、VAR和Dm均从G3开始较年轻组降低（p < 0.05）。结论：正常人黄斑区血管几何参数Df、VAR、Dm与性别、年龄有关，而τn与性别、年龄无关。还获得了两种性别和所有年龄组的黄斑血管几何形状的基线值。
Purpose: To characterize the sex- and age-related alterations of the macular vascular geometry in a population of healthy eyes using fundus photography. Methods: A cross-sectional study was conducted with 610 eyes from 305 healthy subjects (136 men, 169 women) who underwent fundus photography examination and was divided into four age groups (G1 with age ≤ 25 years, G2 with age 26–35 years, G3 with age 36–45 years, and G4 with age ≥ 46 years). A self-developed automated retinal vasculature analysis system allowed segmentation and separate multiparametric quantification of the macular vascular network according to the Early Treatment Diabetic Retinopathy Study (ETDRS). Vessel fractal dimension (Df), vessel area rate (VAR), average vessel diameter (Dm), and vessel tortuosity (τn) were acquired and compared between sex and age groups. Results: There was no significant difference between the mean age of male and female subjects (32.706 ± 10.372 and 33.494 ± 10.620, respectively, p > 0.05) and the mean age of both sexes in each age group (p > 0.05). The Df, VAR, and Dm of the inner ring, the Df of the outer ring, and the Df and VAR of the whole macula were significantly greater in men than women (p < 0.001, p < 0.001, p < 0.05, respectively). There was no significant change of τn between males and females (p > 0.05). The Df, VAR, and Dm of the whole macula, the inner and outer rings associated negatively with age (p < 0.001), whereas the τn showed no significant association with age (p > 0.05). Comparison between age groups observed that Df started to decrease from G2 compared with G1 in the inner ring (p < 0.05) and Df, VAR, and Dm all decreased from G3 compared with the younger groups in the whole macula, inner and outer rings (p < 0.05). Conclusion: In the healthy subjects, macular vascular geometric parameters obtained from fundus photography showed that Df, VAR, and Dm are related to sex and age while τn is not. The baseline values of the macular vascular geometry were also acquired for both sexes and all age groups.
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