Reproducibility of Retinal Microvascular Traits Decoded by the Singapore I Vessel Assessment Software Across the Human Age Range.
Reproducibility of Retinal Microvascular Traits Decoded by the Singapore I Vessel Assessment Software Across the Human Age Range.
复制标题
新加坡 I 血管评估软件在人类年龄范围内解码的视网膜微血管特征的再现性
DOI：
10.1093/ajh/hpx202
复制
发表时间：
2018-03-10
影响因子：
3.2
通讯作者：
Staessen JA
中科院分区：
文献类型：
--
作者：
Huang QF;Wei FF;Zhang ZY;Raaijmakers A;Asayama K;Thijs L;Yang WY;Mujaj B;Allegaert K;Verhamme P;Struijker-Boudier HAJ;Li Y;Staessen JA
视网膜微血管特征预测不良健康结果。新加坡I血管评估（SIVA）软件改进了视网膜照片的自动后处理。除了微血管口径，它还可以测量小动脉和小静脉的几何形状。很少有研究涉及SIVA测量在广泛年龄范围内的可重复性。方法：在本研究中，2名盲法分级者阅读了20名11岁儿童（早产儿（n = 10）或足月儿（n = 10））和60名成人（年龄范围，18.9-86.1岁）通过非散瞳视网膜摄影获得的图像两次。结果：与足月儿相比，早产儿微血管直径较低，血管几何结构紊乱，观察者内和观察者间变异性无差异。在成年人中，微血管口径随年龄和血压而减小，微动脉几何形状与女性性别和年龄呈负相关。通过Bland-Altman方法估计的观察者内差异对于任何测量均未达到显著性。在所有测量中，以平均性状值的百分比表示的中位数再现性（RM）在儿童中为8.8%（中位数组内相关系数[ICC]，0.94），在成人中为8.0%（0.97）。同样，观察者间差异也没有达到显著性，儿童和成人的RM（ICC）分别为10.6%（0.85）和10.4%（0.93）。微血管口径的重现性最好（观察者内/观察者间RM，4.7%/6.0%; ICC，0.98/0.96），小静脉几何形状的重现性最差（17.0%/18.8%; 0.93/0.84），小动脉几何形状的重现性居中（10.9%/14.9%; 0.95/0.86）。结论：SIVA可重复测量早产儿、足月儿和成人的视网膜微血管，从而证明其从儿童到老年的可用性。
Abstract BACKGROUND Retinal microvascular traits predict adverse health outcomes. The Singapore I Vessel Assessment (SIVA) software improved automated postprocessing of retinal photographs. In addition to microvessel caliber, it generates measures of arteriolar and venular geometry. Few studies addressed the reproducibility of SIVA measurements across a wide age range. METHODS In the current study, 2 blinded graders read images obtained by nonmydriatic retinal photography twice in 20 11-year-old children, born prematurely (n = 10) or at term (n = 10) and in 60 adults (age range, 18.9–86.1 years). RESULTS Former preterm compared with term children had lower microvessel diameter and disorganized vessel geometry with no differences in intraobserver and interobserver variability. Among adults, microvessel caliber decreased with age and blood pressure and arteriolar geometry was inversely correlated with female sex and age. Intraobserver differences estimated by the Bland–Altman method did not reach significance for any measurement. Across measurements, median reproducibility (RM) expressed as percent of the average trait value was 8.8% in children (median intraclass correlation coefficient [ICC], 0.94) and 8.0% (0.97) in adults. Likewise, interobserver differences did not reach significance with RM (ICC) of 10.6% (0.85) in children and 10.4% (0.93) in adults. Reproducibility was best for microvessel caliber (intraobserver/interobserver RM, 4.7%/6.0%; ICC, 0.98/0.96), worst for venular geometry (17.0%/18.8%; 0.93/0.84), and intermediate for arteriolar geometry (10.9%/14.9%; 0.95/0.86). CONCLUSIONS SIVA produces repeatable measures of the retinal microvasculature in former preterm and term children and in adults, thereby proving its usability from childhood to old age.
登录
查看更多内容
影响因子：
4.2
作者：
PARR, JC;SPEARS, GFS
通讯作者：
SPEARS, GFS
影响因子：
1.7
作者：
Roelants, M.;Hauspie, R.;Hoppenbrouwers, K.
通讯作者：
Hoppenbrouwers, K.
影响因子：
2.4
作者：
Hussain, Sultana Monira;Kahonen, Mika;Tapp, Robyn J.
通讯作者：
Tapp, Robyn J.
影响因子：
13.7
作者：
Hubbard, LD;Brothers, RJ;Cai, JW
通讯作者：
Cai, JW
影响因子：
2.7
作者：
Cheung, Carol Y.;Chen, Christopher;Wong, Tien Y.
通讯作者：
Wong, Tien Y.