FIT-Binding Proteins and Their Functions in the Regulation of Fe Homeostasis

FIT-Binding Proteins and Their Functions in the Regulation of Fe Homeostasis
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FIT 结合蛋白及其在铁稳态调节中的功能

DOI:
10.3389/fpls.2019.00844
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发表时间:
2019-06
影响因子:
5.6
通讯作者:
Hong-Qing Ling
Hong-Qing Ling
中科院分区:
生物学2区
文献类型:
--
作者:
Huilan Wu;Hong-Qing Ling

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铁作为一种必需的微量营养素,是所有生物体所必需的。在植物中,铁的缺乏和过量都会损害其生长和发育。为了维持适当的细胞内铁浓度,植物进化出不同的调节机制来严格控制铁的吸收、转运和储存。 FIT 是一种 bHLH 转录因子,是拟南芥缺铁反应和体内平衡的主要调节因子。它与不同的蛋白质相互作用,控制涉及铁吸收和体内平衡的各种基因的表达。在这篇综述中,我们总结了FIT和FIT结合蛋白的研究进展,并对FIT在缺铁反应和稳态中的调节网络进行了概述。
Iron, as an essential micronutrient, is required by all living organisms. In plants, the deficiency and excess of iron will impair their growth and development. For maintaining a proper intracellular iron concentration, plants evolved different regulation mechanisms to tightly control iron uptake, translocation and storage. FIT, a bHLH transcription factor, is the master regulator of the iron deficiency responses and homeostasis in Arabidopsis. It interacts with different proteins, functioning in controlling the expression of various genes involved in iron uptake and homeostasis. In this review, we summarize the recent progress in the studies of FIT and FIT-binding proteins, and give an overview of FIT-regulated network in iron deficiency response and homeostasis.
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