Histone Deacetylases Inhibitors in the Treatment of Retinal Degenerative Diseases: Overview and Perspectives.
Histone Deacetylases Inhibitors in the Treatment of Retinal Degenerative Diseases: Overview and Perspectives.
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组蛋白脱乙酰酶抑制剂治疗视网膜退行性疾病：概述和展望
DOI：
10.1155/2015/250812
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发表时间：
2015
影响因子：
1.9
通讯作者：
Pang JJ
中科院分区：
文献类型：
--
作者：
Zhang H;Dai X;Qi Y;He Y;Du W;Pang JJ
视网膜变性疾病是重要的难治性眼科疾病之一，其特征是感光细胞凋亡。组蛋白乙酰化和去乙酰化可调节染色体组装、基因转录和翻译后修饰，分别受组蛋白乙酰转移酶（HAT）和组蛋白去乙酰化酶（HDAC）的调控。组蛋白去乙酰化酶抑制剂（HDACis）能够引起组蛋白和非组蛋白的高度乙酰化，从而对细胞增殖、分化、抗炎和抗凋亡产生多种作用。几种HDAC已被批准用于治疗癌症的临床试验。研究表明，HDACis在神经系统损伤中具有神经保护作用。本文就常见的HDACis在视网膜变性疾病中的神经保护作用进行综述，并对HDACis在视网膜变性疾病治疗中的应用前景进行前景展望。
Retinal degenerative diseases are one of the important refractory ophthalmic diseases, featured with apoptosis of photoreceptor cells. Histone acetylation and deacetylation can regulate chromosome assembly, gene transcription, and posttranslational modification, which are regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), respectively. The histone deacetylase inhibitors (HDACis) have the ability to cause hyperacetylation of histone and nonhistone proteins, resulting in a variety of effects on cell proliferation, differentiation, anti-inflammation, and anti-apoptosis. Several HDACis have been approved for clinical trials to treat cancer. Studies have shown that HDACis have neuroprotective effects in nervous system damage. In this paper, we will summarize the neuroprotective effects of common HDACis in retinal degenerative diseases and make a prospect to the applications of HDACis in the treatment of retinal degenerative diseases in the future.
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影响因子：
3.7
作者：
Chuang MJ;Wu ST;Tang SH;Lai XM;Lai HC;Hsu KH;Sun KH;Sun GH;Chang SY;Yu DS;Hsiao PW;Huang SM;Cha TL
通讯作者：
Cha TL
影响因子：
7.3
作者：
Chen, S. H.;Wu, H. M.;Lu, R. B.
通讯作者：
Lu, R. B.
影响因子：
5.6
作者：
Assem, El-Sayed K.;Peh, Kheng H.;Marson, Charles M.
通讯作者：
Marson, Charles M.
影响因子：
4.1
作者：
Clemson, C. M.;Tzekov, R.;Kaushal, S.
通讯作者：
Kaushal, S.
影响因子：
7.8
作者：
Bandyopadhyay D;Curry JL;Lin Q;Richards HW;Chen D;Hornsby PJ;Timchenko NA;Medrano EE
通讯作者：
Medrano EE