The cholinergic hypothesis of cognitive aging revisited again: cholinergic functional compensation.
The cholinergic hypothesis of cognitive aging revisited again: cholinergic functional compensation.
复制标题
DOI：
10.1016/j.pbb.2011.02.022
复制
发表时间：
2011-08
影响因子：
3.6
通讯作者：
Newhouse, Paul A.
中科院分区：
文献类型：
--
作者：
Dumas, Julie A.;Newhouse, Paul A.
现在有可能重新评估胆碱能假说的年龄相关的认知功能障碍的基础上合成的新证据胆碱能刺激的研究和认知模型。我们建议，通过结合药理学挑战和功能性神经影像学可以观察到的功能电路的变化与胆碱能系统功能的年龄相关变化有关。使用胆碱能激动剂和拮抗剂的精神药理学操作在功能成像研究中看到的衰老复制模式是一致的。此外，抗胆碱酯酶药物在阿尔茨海默病和轻度认知障碍患者中的研究表明，胆碱能补偿导致与任务相关的大脑活动改变的提议得到了支持。因此，胆碱能假说的年龄相关的认知功能障碍值得进一步考虑的新方法来评估其有效性越来越多地被使用。未来的方向，从这个模型产生的假设进行测试。
It is now possible to reevaluate the cholinergic hypothesis of age-related cognitive dysfunction based on a synthesis of new evidence from cholinergic stimulation studies and cognitive models. We propose that a change of functional circuitry that can be observed through a combination of pharmacologic challenge and functional neuroimaging is associated with age-related changes in cholinergic system functioning. Psychopharmacological manipulations using cholinergic agonists and antagonists have been consistent in replicating patterns of aging seen in functional imaging studies. In addition, studies of anticholinesterase drugs in patients with Alzheimer’s disease and mild cognitive impairment show support for the proposal that cholinergic compensation causes alterations in task-related brain activity. Thus, the cholinergic hypothesis of age-related cognitive dysfunction deserves further consideration as new methodologies for evaluating its validity are increasingly being used. Future directions for testing hypotheses generated from this model are presented.
登录
查看更多内容
影响因子：
3.7
作者：
Baltes, PB;Lindenberger, U
通讯作者：
Lindenberger, U
影响因子：
8.2
作者：
Braver, TS;Barch, DA
通讯作者：
Barch, DA
影响因子：
3.7
作者：
Davis, Simon W.;Dennis, Nancy A.;Cabeza, Roberto
通讯作者：
Cabeza, Roberto
影响因子：
158.5
作者：
DAVIS, KL;THAL, LJ;DOODY, RS
通讯作者：
DOODY, RS
DOI：
10.1093/brain/awm299
发表时间：
2008-02
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Bentley P;Driver J;Dolan RJ
通讯作者：
Dolan RJ