On the contribution of deoxy-hemoglobin to MRI gray-white matter phase contrast at high field.
On the contribution of deoxy-hemoglobin to MRI gray-white matter phase contrast at high field.
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DOI：
10.1016/j.neuroimage.2009.07.017
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发表时间：
2010-01-01
期刊：
影响因子：
5.7
通讯作者：
Duyn, Jeff H.
中科院分区：
文献类型：
--
作者：
Lee, Jongho;Hirano, Yoshiyuki;Fukunaga, Masaki;Silva, Afonso C.;Duyn, Jeff H.
基于信号相位的高场（≥ 7 T）MRI研究已用于改善脑精细结构的可视化，最显著的是主要白色物质纤维束、灰-白色物质细分和层状皮质结构。所观察到的对比度已部分归因于存储蛋白质和组织脂质中的铁所产生的磁化率的局部变化。另一个贡献可能来自顺磁性血液成分脱氧血红蛋白，其组织浓度可能因血管密度的局部变化而变化。为了研究这种可能性，我们检查了静脉注射不同剂量的超顺磁性造影剂后大鼠灰色和白色物质之间的相位差。在最大剂量（3 mg Fe/kg）下，估计顺磁磁化率偏移比脱氧血红蛋白大4-8倍，我们观察到灰色和白色物质之间的相位对比度增加可忽略不计。这一结果表明，内源性脱氧血红蛋白之间的灰色和白色物质的相位差没有显着的贡献。
High field (≥ 7 T) MRI studies based on signal phase have been used to improve visualization of the fine structure of the brain, most notably the major white matter fiber bundles, the gray-white matter subdivision, and the laminar cortical architecture. The observed contrast has been attributed in part to local variations in magnetic susceptibility arising from iron in storage proteins and tissue lipid. Another contribution could come from the paramagnetic blood constituent deoxy-hemoglobin, the tissue concentration of which may vary through local variations in vascular density. To investigate this possibility, we examined phase contrast between gray and white matter in rats after intravenous administration of a superparamagnetic contrast agent at various dosages. At the maximum dosage (3 mg Fe/kg), which resulted in an estimated paramagnetic susceptibility shift 4–8 times larger than deoxy-hemoglobin, we observed a negligible increase in phase contrast between gray and white matter. This result suggests that endogenous deoxy-hemoglobin has no significant contribution to phase contrast between gray and white matter.
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DOI：
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发表时间：
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影响因子：
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