Plasma homocysteine levels predict early recurrence after catheter ablation of persistent atrial fibrillation
Plasma homocysteine levels predict early recurrence after catheter ablation of persistent atrial fibrillation
复制标题
血浆同型半胱氨酸水平预测持续性心房颤动导管消融后的早期复发
DOI：
10.1093/europace/euw081
复制
发表时间：
2016-05
期刊：
影响因子：
6.1
通讯作者：
Ma CS
中科院分区：
文献类型：
--
作者：
Du X;Liu XH;Dong JZ;Ma CS
目的探讨血浆同型半胱氨酸（Hcy）水平与持续性心房颤动（房颤）患者单次消融术后早期复发的关系及其预测价值。方法和结果257例持续性房颤患者成功接受导管消融术。消融术后3个月内记录了房性快速性心律失常的早期复发。采用Logistic回归分析和Kaplan-Meier曲线分析同型半胱氨酸与早期复发的关系。在3个月随访期间，75例（29.2%）患者复发。早期复发患者年龄大、左房内径大、CHA 2DS 2-VASc评分高（均P< 0.001）。有早期复发者血浆Hcy水平明显高于无早期复发者（15.1 ± 4.1 vs. 12.4 ± 3.7 µmol/L，P< 0.001）。多因素分析显示，Hcy与早期复发显著相关（OR 1.188，95% CI 1.097-1.286，P< 0.001）。Hcy的AUC为0.688（95% CI为0.623-0.753，P< 0.001）。Hcy的最佳临界值为14 μmol/L（敏感性69%，特异性59%）。Hcy ≥14 µmol/L患者的早期复发率高于Hcy <14 µmol/L患者（41% vs. 22%，P= 0.006）。结论血浆Hcy水平与持续性房颤患者导管消融术后快速房性心律失常的早期复发有关，在预测早期复发时应予以考虑。
Aims To assess the association and the predictive value of plasma homocysteine (Hcy) with early recurrence in persistent atrial fibrillation patients after a single ablation procedure. Methods and results Two hundred and fifty-seven consecutive patients with persistent atrial fibrillation who underwent successful catheter ablation were enrolled. Early recurrence of atrial tachyarrhythmia was documented within 3 months after ablation. The logistic regression analysis and Kaplan–Meier curve analysis were used to evaluate the association of Hcy with early recurrence. During the 3-month follow-up, 75 (29.2%) patients experienced recurrence. Patients with early recurrence were older, more likely to have larger left atrial diameter and higher CHA2DS2-VASc score (all P< 0.001). Plasma Hcy levels were significantly elevated in patients with early recurrence compared with those without early recurrence (15.1 ± 4.1 vs. 12.4 ± 3.7 µmol/L, P< 0.001). In multivariate analysis, Hcy was significantly associated with early recurrence (OR 1.188, 95% CI 1.097–1.286, P< 0.001). Hcy demonstrated a predictive value with AUC of 0.688 (95% CI 0.623–0.753, P< 0.001). The optimal cut-off value was 14 µmol/L for Hcy (sensitivity 69%, specificity 59%). Patients with Hcy ≥14 µmol/L had higher early recurrence rate compared with those with Hcy <14 µmol/L (41 vs. 22%, P= 0.006). Conclusion Plasma Hcy levels are associated with early recurrence of atrial tachyarrhythmia after catheter ablation in persistent atrial fibrillation patients, thus it should be taken into account in prediction of early recurrence.
登录
查看更多内容
DOI：
10.1016/j.jtcvs.2012.07.099
发表时间：
2013-10-01
影响因子：
6
作者：
Nasso, Giuseppe;Bonifazi, Raffaele;Speziale, Giuseppe
通讯作者：
Speziale, Giuseppe
影响因子：
3.3
作者：
Miyazaki, Shinsuke;Taniguchi, Hiroshi;Iesaka, Yoshito
通讯作者：
Iesaka, Yoshito
影响因子：
1.5
作者：
Naji, Franjo;Suran, David;Sabovic, Miso
通讯作者：
Sabovic, Miso
影响因子：
39.3
作者：
Sundströma, J;Sullivan, L;Vasan, RS
通讯作者：
Vasan, RS
影响因子：
8.4
作者：
Kornej, Jelena;Hindricks, Gerhard;Bollmann, Andreas
通讯作者：
Bollmann, Andreas