Hyperoxemic reperfusion after prolonged cardiac arrest in a rat cardiopulmonary bypass resuscitation model.
Hyperoxemic reperfusion after prolonged cardiac arrest in a rat cardiopulmonary bypass resuscitation model.
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DOI：
10.1016/j.resuscitation.2012.08.323
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发表时间：
2013-01
期刊：
影响因子：
6.5
通讯作者：
Angelos MG
中科院分区：
文献类型：
--
作者：
Yeh ST;Aune SE;Wilgus TA;Parent AE;Angelos MG
The effect of hyperoxygenation at reperfusion, particularly in the setting of cardiac arrest, remains unclear. This issue was studied in a prolonged cardiac arrest model consisting of 25 minutes cardiac arrest in a rat resuscitated with cardiopulmonary bypass (CPB). The objective of this study was to determine the effect of hyperoxygenation following prolonged cardiac arrest resuscitation on mitochondrial and cardiac function. Male Sprague-Dawley rats (400–450 g) were anesthetized with ketamine and xylazine and instrumented for closed chest cardiopulmonary bypass (CPB). Following a 25-minute KCl-induced cardiac arrest, the animals were resuscitated by CPB with 100% oxygen. Three minutes after successful return of spontaneous circulation (ROSC), the animals received either normoxemic reperfusion (CPB with 40–50% oxygen) or hyperoxemic reperfusion (CPB with 100% oxygen) for one hour. Post-resuscitation hemodynamics, cardiac function, mitochondrial function and immunostaining of 3-nitrotyrosine were compared between the two different treatment groups. At one hour after ROSC, the hyperoxemic reperfusion group had a significant higher mean arterial pressure, less metabolic acidosis and better diastolic function than the normoxemic reperfusion group. Cardiac mitochondria from the hyperoxemic reperfusion group had a higher respiratory control ratio (RCR) and cardiac tissue showed less nitroxidative stress compared to the normoxemic reperfusion group. One hour of hyperoxemic reperfusion after 25 minutes of cardiac arrest in an in vivo CPB model resulted in significant short-term improvement in myocardial and mitochondrial function compared with one hour of normoxemic reperfusion. This myocardial response may differ from previously reported post-arrest hyperoxia mediated effects following shorter arrest times.
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影响因子：
6.5
作者：
Angelos, Mark G;Yeh, Steve T;Aune, Sverre E
通讯作者：
Aune, Sverre E
影响因子：
120.7
作者：
Kilgannon, J. Hope;Jones, Alan E.;Trzeciak, Stephen
通讯作者：
Trzeciak, Stephen
DOI：
10.1051/ject/2004364391
发表时间：
2004-12-01
期刊：
The journal of extra-corporeal technology
影响因子：
--
作者：
Hoffman, John W Jr;Gilbert, Timothy B;Silldorff, Erik P
通讯作者：
Silldorff, Erik P
DOI：
10.1253/jcj.65.213
发表时间：
2001-03-01
期刊：
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION
影响因子：
--
作者：
Kaneda, T;Ku, K;Oku, H
通讯作者：
Oku, H
影响因子：
4.8
作者：
KELLY, RF;HURSEY, TL;SCHAER, GL
通讯作者：
SCHAER, GL