Cardiovascular and renal effects of weight reduction in obesity and the metabolic syndrome.
Cardiovascular and renal effects of weight reduction in obesity and the metabolic syndrome.
复制标题
肥胖和代谢综合征体重减轻的心血管和肾脏影响。
DOI：
10.1007/s11906-015-0544-2
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发表时间：
2015-05
影响因子：
5.6
通讯作者：
Cohen, Debbie L.
中科院分区：
文献类型：
--
作者：
Cohen, Jordana B.;Cohen, Debbie L.
关键词：
肥胖症是一个严重的全球公共卫生问题。与一般人群相比，肥胖患者的发病率和死亡率显著增加。肥胖增加的健康风险部分是由于其与代谢综合征的其他组成部分，包括高血压，血脂异常和胰岛素抵抗的密切相关。因此，肥胖个体患心血管疾病和慢性肾病的风险特别高。适度的减肥可以改善血清胆固醇水平、血压和血糖水平。长期以来，减肥的生活方式干预一直是肥胖症治疗的支柱。然而，现有文献表明，使用这些方式的减肥可持续性有限，心血管和肾脏获益不一致。除了改善中等风险因素外，手术干预对长期心血管和肾脏结局的影响更持久，但由于围手术期并发症，短期风险更高。
Obesity is a critical public health issue worldwide. Patients with obesity have markedly increased morbidity and mortality compared to the general population. The increased health risks of obesity in part are due to its close association with each of the other components of the metabolic syndrome, including hypertension, dyslipidemia, and insulin resistance. Accordingly, obese individuals are at particularly increased risk of cardiovascular disease and chronic kidney disease. Modest weight loss results in improvements in serum cholesterol levels, blood pressure, and glycemic profiles. Lifestyle interventions for weight loss have long been the mainstay of treatment in obesity. However, the existing literature demonstrates limited weight loss sustainability and inconsistent cardiovascular and renal benefits using these modalities. In addition to improvements in intermediate risk factors, surgical interventions provide a more lasting impact on long-term cardiovascular and renal outcomes, though carry higher short-term risks due to perioperative complications.
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影响因子：
16.9
作者：
Halperin, Florencia;Ding, Su-Ann;Simonson, Donald C.;Panosian, Jennifer;Goebel-Fabbri, Ann;Wewalka, Marlene;Hamdy, Osama;Abrahamson, Martin;Clancy, Kerri;Foster, Kathleen;Lautz, David;Vernon, Ashley;Goldfine, Allison B.
通讯作者：
Goldfine, Allison B.
影响因子：
120.7
作者：
Flegal, KM;Carroll, MD;Johnson, CL
通讯作者：
Johnson, CL
影响因子：
3.1
作者：
Alexander, J. Wesley;Goodman, Hope R.;Cardi, Michael A.
通讯作者：
Cardi, Michael A.
DOI：
10.1038/nrendo.2014.44
发表时间：
2014-06
期刊：
Nature reviews. Endocrinology
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.4
作者：
Cawley, John;Meyerhoefer, Chad;Wintfeld, Neil
通讯作者：
Wintfeld, Neil