Determinants and interindividual variation of R-R interval dynamics in healthy middle-aged subjects.

Determinants and interindividual variation of R-R interval dynamics in healthy middle-aged subjects.
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健康中年受试者 R-R 间期动态的决定因素和个体间变异。

DOI:
10.1152/ajpheart.2001.280.3.h1400
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发表时间:
2001
期刊:
American journal of physiology. Heart and circulatory physiology
影响因子:
--
通讯作者:
H. Huikuri
H. Huikuri
中科院分区:
--
文献类型:
--
作者:
Sirkku M. Pikkujämsä;Timo H. Mäkikallio;K. Airaksinen;H. Huikuri

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随机选取200名健康中年女性(年龄51 ± 6岁)和189名男性(年龄50 ± 6岁),在仰卧位和坐位的受控条件下,研究R-R间期变异性的分形和复杂性指标的决定因素和受试者间变异。短期分形指数(alpha(1))在仰卧位(1.18 +/- 0.20 vs. 1.12 +/- 0.17,P < 0.01)和坐位(P < 0.001)时女性均低于男性。近似熵(ApEn)是一种复杂性的度量,女性在坐姿时更高(1.16 +/- 0.17 vs. 1.07 +/- 0.19,P < 0.001),但在仰卧位时没有观察到与性别相关的ApEn差异。分形和复杂性指标与任何其他人口统计学、实验室或生活方式因素无关。分形测量中的受试者间变化,alpha(1)(例如,1.15+/- 0.20,仰卧位,z值1.24,不显著),以及在复杂性测量中,ApEn(例如,1.14+/-0.18,Z值1.44,不显著),通常比心率变异性的传统测量中的变化更小并且更正态分布(例如,仰卧位时R-R间期的标准差为49 ± 21 ms,z值为2.53,P < 0.001)。这些结果在一个大的随机人群样本中表明,健康受试者表达相对较小的个体间变异的分形和复杂性的措施,心率行为和,不像传统的心率变异性的措施,他们是不相关的生活方式,代谢,或人口统计学变量。然而,在心率行为的分形和复杂性测量中也存在与性别相关的细微差异。
Determinants and intersubject variations of fractal and complexity measures of R-R interval variability were studied in a random population of 200 healthy middle-aged women (age 51 +/- 6 yr) and 189 men (age 50 +/- 6 yr) during controlled conditions in the supine and sitting positions. The short-term fractal exponent (alpha(1)) was lower in women than men in both the supine (1.18 +/- 0.20 vs. 1.12 +/- 0.17, P < 0.01) and sitting position (P < 0.001). Approximate entropy (ApEn), a measure of complexity, was higher in women in the sitting position (1.16 +/- 0.17 vs. 1.07 +/- 0.19, P < 0.001), but no gender-related differences were observed in ApEn in the supine position. Fractal and complexity measures were not related to any other demographic, laboratory, or lifestyle factors. Intersubject variations in a fractal measure, alpha(1) (e.g., 1.15 +/- 0.20 in the supine position, z value 1.24, not significant), and in a complexity measure, ApEn (e.g., 1.14 +/- 0.18 in the supine position, z value 1.44, not significant), were generally smaller and more normally distributed than the variations in the traditional measures of heart rate variability (e.g., standard deviation of R-R intervals 49 +/- 21 ms in the supine position, z value 2.53, P < 0.001). These results in a large random population sample show that healthy subjects express relatively little interindividual variation in the fractal and complexity measures of heart rate behavior and, unlike the traditional measures of heart rate variability, they are not related to lifestyle, metabolic, or demographic variables. However, subtle gender-related differences are also present in fractal and complexity measures of heart rate behavior.
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影响因子: 24
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DOI: 10.1161/01.res.68.4.966
发表时间: 1991-04
影响因子: 20.1
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影响因子: 2.8
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