High resolution and contrast 7 tesla MR brain imaging of the neonate.
High resolution and contrast 7 tesla MR brain imaging of the neonate.
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DOI：
10.3389/fradi.2023.1327075
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Arichi, Tomoki
中科院分区：
文献类型：
--
作者：
Bridgen, Philippa;Tomi-Tricot, Raphael;Uus, Alena;Cromb, Daniel;Quirke, Megan;Almalbis, Jennifer;Bonse, Beya;Botella, Miguel de la Fuente;Maggioni, Alessandra;Di Cio, Pierluigi;Cawley, Paul;Casella, Chiara;Dokumaci, Ayse Sila;Thomson, Alice R.;Moore, Jucha Willers;Bridglal, Devi;Saravia, Joao;Finck, Thomas;Price, Anthony N.;Pickles, Elisabeth;Cordero-Grande, Lucilio;Egloff, Alexia;O'Muircheartaigh, Jonathan;Counsell, Serena J.;Giles, Sharon L.;Deprez, Maria;De Vita, Enrico;Rutherford, Mary A.;Edwards, A. David;Hajnal, Joseph V.;Malik, Shaihan J.;Arichi, Tomoki
超高场磁共振成像在信噪比、空间分辨率和对比度方面有显著提高，从而提高了病理和解剖灵敏度。这些好处与新生儿大脑特别相关，因为新生儿大脑发育迅速，对损伤很敏感。然而，由于法规、安全和实际考虑，7T新生儿成像的经验有限。我们的目标是建立一个程序，以安全获取新生儿的高分辨率和对比度的大脑图像在7T系统。在平均49分钟30秒的时间内，对35名新生儿进行了44次成像（平均年龄39 + 6周，范围33 + 4至52 + 6；平均体重2.93 kg，范围1.57至5.3 kg）。扫描过程中记录外周体温和生理指标。获得的序列包括T2加权（TSE）、实际翻转角成像（AFI）、功能MRI （BOLD EPI）、敏感性加权成像（SWI）和磁共振光谱（STEAM）。扫描前后的温度没有显著差异（p = 0.76），与最先进的3T采集相比，图像质量评估有利。解剖成像显示对低场强下难以观察的结构（包括海马、小脑和脉管系统）具有良好的敏感性。图像也通过对比机制获得，在超高场下增强，包括磁化率加权成像，功能MRI和MR光谱。我们证明了超高场成像脆弱新生儿的安全性和可行性，并强调了在生命早期这一关键阶段为大脑发育和病理过程提供重要新见解的未开发潜力。
Ultra-high field MR imaging offers marked gains in signal-to-noise ratio, spatial resolution, and contrast which translate to improved pathological and anatomical sensitivity. These benefits are particularly relevant for the neonatal brain which is rapidly developing and sensitive to injury. However, experience of imaging neonates at 7T has been limited due to regulatory, safety, and practical considerations. We aimed to establish a program for safely acquiring high resolution and contrast brain images from neonates on a 7T system. Images were acquired from 35 neonates on 44 occasions (median age 39 + 6 postmenstrual weeks, range 33 + 4 to 52 + 6; median body weight 2.93 kg, range 1.57 to 5.3 kg) over a median time of 49 mins 30 s. Peripheral body temperature and physiological measures were recorded throughout scanning. Acquired sequences included T2 weighted (TSE), Actual Flip angle Imaging (AFI), functional MRI (BOLD EPI), susceptibility weighted imaging (SWI), and MR spectroscopy (STEAM). There was no significant difference between temperature before and after scanning (p = 0.76) and image quality assessment compared favorably to state-of-the-art 3T acquisitions. Anatomical imaging demonstrated excellent sensitivity to structures which are typically hard to visualize at lower field strengths including the hippocampus, cerebellum, and vasculature. Images were also acquired with contrast mechanisms which are enhanced at ultra-high field including susceptibility weighted imaging, functional MRI, and MR spectroscopy. We demonstrate safety and feasibility of imaging vulnerable neonates at ultra-high field and highlight the untapped potential for providing important new insights into brain development and pathological processes during this critical phase of early life.
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影响因子：
8.3
作者：
Bonthrone, Alexandra F.;Stegeman, Raymond;Feldmann, Maria;Claessens, Nathalie H. P.;Nijman, Maaike;Jansen, Nicolaas J. G.;Nijman, Joppe;Groenendaal, Floris;de Vries, Linda S.;Benders, Manon J. N. L.;Haas, Felix;Bekker, Mirielle N.;Logeswaran, Thushiha;Reich, Bettina;Kottke, Raimund;Hagmann, Cornelia;Latal, Beatrice;Dave, Hitendu;Simpson, John;Pushparajah, Kuberan;Austin, Conal;Kelly, Christopher J.;Arulkumaran, Sophie;Rutherford, Mary A.;Counsell, Serena J.;Knirsch, Walter;Breur, Johannes M. P. J.
通讯作者：
Breur, Johannes M. P. J.
影响因子：
11.2
作者：
Kolb, Hadar;Absinta, Martina;Beck, Erin S.;Ha, Seung-Kwon;Song, Yeajin;Norato, Gina;Cortese, Irene;Sati, Pascal;Nair, Govind;Reich, Daniel S.
通讯作者：
Reich, Daniel S.
DOI：
10.1111/jcpp.12838
发表时间：
2018-04
期刊：
Journal of child psychology and psychiatry, and allied disciplines
影响因子：
--
作者：
Batalle D;Edwards AD;O'Muircheartaigh J
通讯作者：
O'Muircheartaigh J
影响因子：
2.9
作者：
Malik, Shaihan J.;Beqiri, Arian;Price, Anthony N.;Teixeira, Jose Nuno;Hand, Jeffrey W.;Hajnal, Joseph V.
通讯作者：
Hajnal, Joseph V.
影响因子：
3.3
作者：
Pohmann, Rolf;Speck, Oliver;Scheffler, Klaus
通讯作者：
Scheffler, Klaus