Annual Research Review: Not just a small adult brain: understanding later neurodevelopment through imaging the neonatal brain.
Annual Research Review: Not just a small adult brain: understanding later neurodevelopment through imaging the neonatal brain.
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DOI：
10.1111/jcpp.12838
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发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
O'Muircheartaigh J
中科院分区：
文献类型：
--
作者：
Batalle D;Edwards AD;O'Muircheartaigh J
近期，神经影像学研究大量涌现，重点关注胎儿期、新生儿期以及幼儿早期的大脑发育。早期脑损伤和早产与神经发育障碍风险增加有关，这表明这一早期阶段对后期结果的重要性。
尽管使用了各种各样的不同方法，研究的样本也各不相同，但许多这类研究的共同目的是追踪正常发育情况，并研究这种发育过程中的偏差以预测儿童时期的行为、认知和神经功能。在此，我们综述了研究发育中大脑的结构和功能神经影像学研究。我们关注研究这一早期年龄段的实际和技术复杂性，并讨论神经影像学技术如何成功应用于研究后期神经发育结果。
后期结果的神经影像学标志物的预测能力仍然低得惊人，它们对个体神经发育障碍的特异性仍然受到质疑。然而，该领域仍处于起步阶段，在获取和模拟新生儿数据方面的重大挑战正在被克服。
阅读本文的评论，请访问doi:10.1111/jcpp.12890
There has been a recent proliferation in neuroimaging research focusing on brain development in the prenatal, neonatal and very early childhood brain. Early brain injury and preterm birth are associated with increased risk of neurodevelopmental disorders, indicating the importance of this early period for later outcome. Although using a wide range of different methodologies and investigating diverse samples, the common aim of many of these studies has been to both track normative development and investigate deviations in this development to predict behavioural, cognitive and neurological function in childhood. Here we review structural and functional neuroimaging studies investigating the developing brain. We focus on practical and technical complexities of studying this early age range and discuss how neuroimaging techniques have been successfully applied to investigate later neurodevelopmental outcome. Neuroimaging markers of later outcome still have surprisingly low predictive power and their specificity to individual neurodevelopmental disorders is still under question. However, the field is still young, and substantial challenges to both acquiring and modeling neonatal data are being met. Read the Commentary on this article at doi: 10.1111/jcpp.12890
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DOI：
10.1523/jneurosci.1929-08.2008
发表时间：
2008-09-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bassett DS;Bullmore E;Verchinski BA;Mattay VS;Weinberger DR;Meyer-Lindenberg A
通讯作者：
Meyer-Lindenberg A
影响因子：
5.7
作者：
Arichi, Tomoki;Fagiolo, Gianlorenzo;Varela, Marta;Melendez-Calderon, Alejandro;Allievi, Alessandro;Merchant, Nazakat;Tusor, Nora;Counsell, Serena J.;Burdet, Etienne;Beckmann, Christian F.;Edwards, A. David
通讯作者：
Edwards, A. David
影响因子：
5.7
作者：
Batalle D;Hughes EJ;Zhang H;Tournier JD;Tusor N;Aljabar P;Wali L;Alexander DC;Hajnal JV;Nosarti C;Edwards AD;Counsell SJ
通讯作者：
Counsell SJ
影响因子：
4.6
作者：
Beul SF;Barbas H;Hilgetag CC
通讯作者：
Hilgetag CC
影响因子：
1
作者：
Bellinger, David C.;Newburger, Jane W.;Rappaport, Leonard A.
通讯作者：
Rappaport, Leonard A.