Quantification of the mechanical behavior of carotid arteries from wild-type, dystrophin-deficient, and sarcoglycan-delta knockout mice.
Quantification of the mechanical behavior of carotid arteries from wild-type, dystrophin-deficient, and sarcoglycan-delta knockout mice.
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DOI：
10.1016/j.jbiomech.2008.08.012
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发表时间：
2008-11-14
影响因子：
2.4
通讯作者：
Humphrey, Jay D.
中科院分区：
文献类型：
--
作者：
Gleason, Rudolph L.;Dye, Wendy W.;Wilson, Emily;Humphrey, Jay D.
由于临床护理的改善，肌肉萎缩症患者的寿命延长，他们将越来越容易患上影响一般人群的许多心血管疾病。因此，迫切需要更好地了解这些患者动脉壁的生物学和力学。在本文中，我们首次使用非线性本构关系来模拟两种常见的肌营养不良小鼠模型（肌营养不良蛋白缺陷和肌聚糖- δ缺失）和野生型对照的颈动脉双轴力学行为。结果表明，结构驱动的四纤维家族应力-应变关系比常用的现象指数模型更好地描述了所有三种基因型的被动行为，而Rachev-Hayashi模型描述了基底张力下平滑肌收缩的力学贡献。由于结构驱动的本构关系可以很容易地扩展到对改变的血流动力学的适应模型，因此本研究的结果代表了朝着更好地理解肌肉萎缩症动脉的机械生物学和病理生理学的最终目标迈出的重要一步。
As patients with muscular dystrophy live longer because of improved clinical care, they will become increasingly susceptible to many of the cardiovascular diseases that affect the general population. There is, therefore, a pressing need to better understand both the biology and the mechanics of the arterial wall in these patients. In this paper, we use nonlinear constitutive relations to model, for the first time, the biaxial mechanical behavior of carotid arteries from two common mouse models of muscular dystrophy (dystrophin deficient and sarcoglycan-delta null) and wild-type controls. It is shown that a structurally motivated four-fiber family stress-strain relation describes the passive behavior of all three genotypes better than does a commonly used phenomenological exponential model, and that a Rachev-Hayashi model describes the mechanical contribution of smooth muscle contraction under basal tone. Because structurally motivated constitutive relations can be extended easily to model adaptations to altered hemodynamics, results from this study represent an important step toward the ultimate goal of understanding better the mechanobiology and pathophysiology of arteries in muscular dystrophy.
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影响因子：
2
作者：
Holzapfel, GA;Gasser, TC;Ogden, RW
通讯作者：
Ogden, RW
影响因子：
20.1
作者：
Loufrani, L;Levy, BI;Henrion, D
通讯作者：
Henrion, D
影响因子：
3.5
作者：
Ito, Kaori;Kimura, Shigemi;Miike, Teruhisa
通讯作者：
Miike, Teruhisa
影响因子：
3.8
作者：
Rachev, A;Hayashi, K
通讯作者：
Hayashi, K
DOI：
10.1115/1.1762899
发表时间：
2004-06-01
影响因子：
1.7
作者：
Gleason, RL;Taber, LA;Humphrey, JD
通讯作者：
Humphrey, JD