Time-course of masked response priming and inhibition in Parkinson's disease
Time-course of masked response priming and inhibition in Parkinson's disease
复制标题
帕金森病的掩蔽反应启动和抑制的时程
DOI：
10.1016/j.neuropsychologia.2005.09.001
复制
发表时间：
2006
期刊：
影响因子：
2.6
通讯作者：
P. Praamstra
中科院分区：
文献类型：
--
作者：
E. Seiss;P. Praamstra
在各种“冲突任务”中，帕金森病患者由于竞争反应之间的冲突而产生的干扰效应增强。这是由于抑制缺陷的可能性最近得到了掩蔽反应启动任务的支持[Seiss， E., & Praamstra， P.(2004)]。反应选择中的基底神经节和抑制机制：来自帕金森病运动反应阈下启动的证据。[j].中国生物医学工程学报，2016,33(4):391 - 391。隐藏启动任务的附加信息是，在启动刺激和目标刺激之间引入延迟，揭示了由隐藏启动刺激诱导的隐蔽反应激活的抑制。这种抑制导致正常启动效应的逆转，因此，不相容的启动-目标对比相容的启动-目标对表现更好。我们之前发现，在帕金森病中，当主要目标延迟100ms时，这种逆转减弱，从而揭示了隐蔽反应激活的抑制不足。本研究旨在研究潜在抑制过程的时间过程，使用0至200ms之间的5个主要目标ISIs。虽然我们重现了ISI 100ms时的衰减，但时间过程信息显示，患者和对照组的相容性效应从0到200ms的变化率是相同的。这一结果表明，隐藏启动效应逆转的抑制在帕金森病中是正常的。
Parkinson's disease patients have enhanced interference effects arising from the conflict between competing responses, as probed in various ‘conflict tasks’. The possibility that this is due to an inhibitory deficit received recent support from a masked response priming task [Seiss, E., & Praamstra, P. (2004). The basal ganglia and inhibitory mechanisms in response selection: Evidence from subliminal priming of motor responses in Parkinson's disease. Brain, 127, 330–339]. The added information from a masked priming task is that the introduction of a delay between presentation of prime and target stimuli reveals an inhibition of the covert response activation induced by the masked prime stimulus. This inhibition results in a reversal of normal priming effects, such that performance is better with incompatible than with compatible prime-target pairs. We previously found that this reversal is attenuated in Parkinson's disease, when tested at a prime-target delay of 100ms, thus revealing deficient inhibition of covert response activation. The present study was undertaken to investigate the time course of the underlying inhibition process, using five prime-target ISIs between 0 and 200ms. While we reproduced the attenuation at ISI 100ms, the time course information revealed that the rate of change of the compatibility effect over ISIs from 0 to 200ms was identical for patients and controls. This result indicates that the inhibition underlying the reversal of masked priming effects is normal in Parkinson's disease.
DOI：
10.1037/0096-1523.14.3.331
发表时间：
1988-08-01
影响因子：
2.1
作者：
GRATTON, G;COLES, MGH;DONCHIN, E
通讯作者：
DONCHIN, E
影响因子：
14.5
作者：
BODISWOLLNER, I;MARX, MS;YAHR, M
通讯作者：
YAHR, M