Differential energetic response of brain vs. skeletal muscle upon glycemic variations in healthy humans.
Differential energetic response of brain vs. skeletal muscle upon glycemic variations in healthy humans.
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健康人血糖变化时大脑与骨骼肌的不同能量反应
DOI：
10.1152/ajpregu.00093.2007
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Pellerin
中科院分区：
文献类型：
--
作者：
Oltmanns;Melchert;Scholand-Engler;Howitz;Schultes;Schweiger;Hohagen;Peters;Pellerin
大脑调节机体内的所有代谢过程，因此，即使在禁食期间，其能量供应也会得到保护。然而，其潜在机制尚不清楚。在这里，它表明，使用31 P-磁共振波谱，在短期的低血糖和高血糖，大脑可以迅速增加其高能磷酸盐含量，而骨骼肌没有变化。本文应用~（31）P磁共振波谱技术对17名健康男性脑和骨骼肌中作为快速能量储备的高能磷酸盐代谢的关键代谢物进行了研究。在基线和葡萄糖或胰岛素诱导的高血糖和低血糖期间进行测量。在高血糖期间，脑中磷酸肌酸（PCr）浓度显著增加（P= 0.013），而在低血糖条件下也有类似的趋势（P= 0.055）。两种条件下，骨骼肌含量保持不变（P> 0.1）。ANOVA分析比较了从基线到大脑（高达+15%）与肌肉（高达-4%）中相应血糖平台的变化，显示了两种情况下明显的差异效应（P< 0.05）。PCr/Pi比值（P< 0.05）反映了上述作用。总ATP浓度显示，观察到的分歧，只有在高血糖症（P= 0.018）。这些数据表明，与外周器官相比，大脑可以激活一些特定的机制来调节其能量状态，在葡萄糖供应的变化。这些机制的紊乱可能对与肥胖或糖尿病相关的代谢失调具有深远的影响。
The brain regulates all metabolic processes within the organism, and therefore, its energy supply is preserved even during fasting. However, the underlying mechanism is unknown. Here, it is shown, using31P-magnetic resonance spectroscopy that during short periods of hypoglycemia and hyperglycemia, the brain can rapidly increase its high-energy phosphate content, whereas there is no change in skeletal muscle. We investigated the key metabolites of high-energy phosphate metabolism as rapidly available energy stores by31P MRS in brain and skeletal muscle of 17 healthy men. Measurements were performed at baseline and during dextrose or insulin-induced hyperglycemia and hypoglycemia. During hyperglycemia, phosphocreatine (PCr) concentrations increased significantly in the brain (P= 0.013), while there was a similar trend in the hypopglycemic condition (P= 0.055). Skeletal muscle content remained constant in both conditions (P> 0.1). ANOVA analyses comparing changes from baseline to the respective glycemic plateau in brain (up to +15%) vs. muscle (up to −4%) revealed clear divergent effects in both conditions (P< 0.05). These effects were reflected by PCr/Pi ratio (P< 0.05). Total ATP concentrations revealed the observed divergency only during hyperglycemia (P= 0.018). These data suggest that the brain, in contrast to peripheral organs, can activate some specific mechanisms to modulate its energy status during variations in glucose supply. A disturbance of these mechanisms may have far-reaching implications for metabolic dysregulation associated with obesity or diabetes mellitus.
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高胰岛素血症和高血糖对健康人皮下脂肪组织乳酸释放和局部血流的影响。
DOI：
10.1210/jcem.81.8.8768847
发表时间：
1996
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
S. Henry;P. Schneiter;E. Jéquier;L. Tappy
通讯作者：
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影响因子：
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影响因子：
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作者：
A. Tarasenko;M. V. Linetska;L. Storchak;N. Himmelreich
通讯作者：
N. Himmelreich
影响因子：
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作者：
Mason, GF;Petersen, KF;Shulman, GI
通讯作者：
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